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논문 기본 정보

자료유형
학술저널
저자정보
정웅기 (연세대학교 의과대학 성형외과학교실, 연세대학교 인체조직복원 연구소) 유대현 (연세대학교 의과대학 성형외과학교실, 연세대학교 인체조직복원 연구소) 박병윤 (연세대학교 의과대학 성형외과학교실, 연세대학교 인체조직복원 연구소)
저널정보
대한미세수술학회 대한미세수술학회지 대한미세수술학회지 제11권 제2호
발행연도
2002.1
수록면
173 - 178 (6page)

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초록· 키워드

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Wound healing is the result of interaction of normal cellular and biochemical responses that restore the interrupted anatomical structure in limited period. When any response of them is impaired, it results in chronic wound. The factors that influence the wound healing process is not only limited to the fundamental disease of the individual but also the local factors, especially various growth factors secreted from the various cells involved in tissue regeneration have important role. Recent reports that the chronic wounds are depleted of these growth factors have led active studies on the alteration of local wound environment with manipulation of the growth factors and the its application in management of chronic wounds. We investigated the effect on the chronic wounds in 10 patients with various pathologic conditions to suggest the appropriate application and guideline of the indication. The chronic wounds resulting from various causes in 10 patients were treated with rhPDGF gel and good wound care. All the chronic wounds were located on the lower extremity and the average diameter was 2.5 cm. 7 patients were completely cured within 8 weeks, however the patient who received previous radiation therapy the healing was delayed to 14 weeks. Two patients with vascular ulcer were not cured with rhPDGF alone. Local application of rhPDGF has yielded complete cure of the chronic wound in 70% of the patients within 2 months. The author suggests that it would be an effective alternative treatment modality of chronic wound when it is applied with good wound care and appropriate indication.

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