지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
이용수
초록· 키워드
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The purpose of this study was to investigate the wound healing effects of Danggwieumja (DG), which is commonly used for skin inflammation, skin wound, skin pruritus, and chronic hives etc. The 1.5 cm × 1.5 cm full-thickness skin wound was induced to two groups, DG (n=16) and Saline (n=16) group. The DG extract and Saline were orally administrated daily for 15 days after skin wound induction. Then, the body weight of rats and the congestion indices were daily measured for 15 days after skin wound induction. The wound contractions and epithelizations were also measured. The wound contractions were daily measured for 15 days after wound induction and wound epithelizations were measured for 8 days from day 7 after wound induction. For evaluating angiogenesis, the immunoreactivities of vWF and VEGF protein were measured immunohistochemistrically on day 15. In results, although the percentage increases in mean body weight of rats in the DG and Saline groups hve no significant differences, DG extract decreased the time of wound healing and congestion around wound, and improved wound contraction and epithelization. The contraction percentage of DG group was significantly increased on day 5 (P<0.05) and day 7 (P<0.01) than that of Saline group. DG group showed significant increase of wound epithelization on day 7 (P<0.05) as compared to Saline group. Moreover, DG extract reduced the inflammation of skin dermis and promoted the growth of vascular vessels of dermis by accelerating vascular endothelial growth factor (VEGF) protein. These results suggest that DG has the beneficial effects on skin incision wound and can be the suitable wound healing agent for various surgical wounds.
목차
Introduction
Materials and Methods
Results
Discussion
Conclusion
References
참고문헌 (29)
참고문헌 신청
HAN, DONGOH / 2007 / Wound Healing Activity of Gamma-Aminobutyric Acid (GABA) in Rats / Journal of Microbiology and Biotechnology 17(10):1661~1669
Clark, R.A / 1985 / Cutaneous tissue repair: basic biologic considerations / I. J Am Acad Dermatol 13(5):701~725
Ermertcan, A.T. / 2008 / Comparison of the effects of collagenase and extract of Centella asiatica in an experimental model of wound healing: an immunohistochemical and histopathological study / Wound Repair Regen 16(5):674~681
Luo, J.D. / 2005 / Nitric oxide: a newly discovered function on wound healing / Acta Pharmacol Sin 26(3):259~264
Singer, A.J. / 1999 / Cutaneous wound healing / N Engl J Med 341(10):738~746
Clark, R.A / 1985 / Cutaneous tissue repair: basic biologic considerations / I. J Am Acad Dermatol 13(5):701~725
Ermertcan, A.T. / 2008 / Comparison of the effects of collagenase and extract of Centella asiatica in an experimental model of wound healing: an immunohistochemical and histopathological study / Wound Repair Regen 16(5):674~681
Luo, J.D. / 2005 / Nitric oxide: a newly discovered function on wound healing / Acta Pharmacol Sin 26(3):259~264
Singer, A.J. / 1999 / Cutaneous wound healing / N Engl J Med 341(10):738~746
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