지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Nitric oxide is a tonically produced vasodilator that maintains blood pressure in the normal animal. The chronic inhibition of nitric oxide synthase (NOS) elicits the hypertension in rats. However, the mechanism of hypertension induced by chronic inhibition of NOS is not clear. Thus, to clarify the mechanism of the occurance of hypertension, the changes in $\alpha$-adrenergic systems in rats treated with NOS inhibitors for 21 days were examined. Chronic administration of L-NAME significantly increased in the basal blood pressure, but chronic administration of 7-nitroindazole did not. Phenylephrine and G-protein stimulator elicited the more potent contraction in the aorta of the L-NAME-induced hypertensive rats. However when the contractile responses by phenylephrine and G-protein stimulator were calculated the proportion to the contraction by 25 mM KCL, there was no difference between the vehicle-treated rats and the L-NAME-treated rats. The density of $\alpha$-adrenergic receptors in aortic tissue was not changed by the chronic inhibition of NOS. These results suggest that hypertension induced by chronic inhibition of NOS is due to the inhibition of eNOS and the increased responses to the adrenergic drugs are due to the changes of the intracellular contactile mechanism of aortic tissue rather than the changes of receptor density.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Nitric Oxide의 만성적인 억제로 인한 고혈압성 SD 랫드에서 Insulin 및 전해질의 변화
Laboratory Animal Research
1999 .09
-
Association between Arg16Gly Mutation in the β₂-Adrenergic Receptor Gene and Hypertension in the Korean Population
한국환경성돌연변이·발암원학회지
2001 .09
-
The Analgesic Effect and the Mechanism of Electroacupuncture on Thermal Hyperalgesia in the Rat Model of Collagenase-induced Arthritis: Mediation by Adrenergic Receptors
대한침구의학회지
2011 .01
-
Developmental Changes of the Alpha1-Adrenergic System in the Rat Heart
한국응용약물학회 추계심포지움자료집
1993 .01
-
2018 Korean Society of Hypertension guidelines for the management of hypertension: part I-epidemiology of hypertension
Clinical Hypertension
2019 .01
-
Beta-Adrenergic Receptor Imaging
대한핵의학회 학술대회
2006 .01
-
Pulmonary Edema following Phenylephrine Intranasal Spray Administration during the Induction of General Anesthesia in a Child
Yonsei Medical Journal
2005 .01
-
Effect of Chronic Inhibition of Nitric Oxide on Blood Pressure and Apoptosis in the Blood Pressure-Associated with Organs
대한의생명과학회지
2010 .03
-
Purification and Characterization of the $\beta$-Adrenergic Receptor from Rat Cerebral Cortex
한국응용약물학회 춘계학술발표논문집
1994 .01
-
지역사회 주민의 고혈압 예방 식이프로그램의 효과 평가
농촌의학·지역보건
2006 .12
-
Alpha 2a Adrenergic Receptor의 유전적 다형성과 멀미 감수성에 관한 연구
항공우주의학 학술대회
2007 .11
-
Induction of selective cell death of culture-adapted human embryonic stem cells through Bcl-XL inhibition
한국실험동물학회 학술발표대회 논문집
2018 .01
-
2013 Korean Society of Hypertension guidelines for the management of hypertension. Part III—hypertension in special situations
Clinical Hypertension
2015 .01
-
일 지역 만성질환관리 건강포인트사업이 고혈압 및 당뇨병관리 지식에 미치는 효과
가정간호학회지
2012 .01
-
Probenecid inhibit $\alpha$-adrenergic receptor mediated vasoconstriction
한국응용약물학회 추계학술발표논문집
2001 .01
-
중추신경계에 미치는 소아 고혈압의 영향
Childhood Kidney Diseases
2011 .01
-
Antihypertensive Effects of the Methanol Extract of Sorbus Cortex in the Nitric Oxide-deficient Hypertensive Rat
동의생리병리학회지
2006 .01
-
흰쥐 hepatocyte에서 알파 및 베타 아드레날린 수용체의 자극에 의한 글리코겐분해에 있어서 칼슘과 니페디핀의 작용
약학회지
1988 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0