지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Biodegradable microspheres made from poly-lactide-co-glycolide polymers have been considered as a new delivery system for single-dose vaccine. Purified tetanus toxoid (TT) was encapsulated in poly-lactide(PLA) and poly-lactide-co-glycolide (PLGA) microparticles using a solvent evaporation method in a multiple emulsion system (water-in oil-in water). The morphology of 77-loaded microparticles was spherical and the suface of them was smooth. The particle size was in a range of 2-10. Protein loading efficiency was 68-97.8%. PLGA (85:15) microparticle showed the highest efficiency. Protein release pattern was influenced by polymer molecular weight and composition. The release rate of PLA(Mw 100,000) microsphere was higher than any other microspheres. In consequence of the hydrolysis of PLGA(50:50) microspheres, environmental pH decreased from 7.4 to 5.0. The PLA, PLGA (75:25) and PLGA (85:15) microshperes showed no significant pH change. The antigenicity or n in microshperes was assayed by indirect sandwich ELISA using equine polyclonal tetanus antitoxin for capture antibody and human polyclonal tetanus antitoxin for primary antibody. The antigenicity of TT in PLA (Mw 100,000), PLGA(50:50, Mw 100,000) and PLGA (75:25, Mw 73,300) after 30 days incubation showed 54, 40.9 and 76.7%, respectively.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
A Comparative study for single-shot immunization of diphtheria toxoid with combined PLGA microspheres.
대한약학회 학술대회
2002 .01
-
Biocompatibility, biodegradation and biomedical applications of poly(lactic acid)/poly(lactic‑co‑glycolic acid) micro and nanoparticles
Journal of Pharmaceutical Investigation
2019 .01
-
Preparation and Therapeutic Evaluation of DNA-Loaded PLGA Microspheres
대한약학회 학술대회
2004 .01
-
Rabbit calvaria를 이용하여 hyaluronic acid (HA)를 처리한 poly (D,L-lactic-co-glycolic acid) 차폐막들의 골 생성능력에 대한 비교 연구
대한치과보철학회지
2010 .01
-
Investigation of PEG Modification Effects on Drug Release from PLGA Microspheres
대한약학회 학술대회
2001 .01
-
Enhanced Antigen Delivery Systems Using Biodegradable PLGA Microspheres for Single Step Immunization
대한의생명과학회지
2006 .12
-
PEGylated polylactide (PLA) and poly (lactic‑co‑glycolic acid) (PLGA) copolymers for the design of drug delivery systems
Journal of Pharmaceutical Investigation
2019 .01
-
PLGA-Based Nanoparticles as Cancer Drug Delivery Systems
Asian Pacific journal of cancer prevention : APJCP
2014 .01
-
FITC Albumin degradation and release from PLGA microsphere
대한약학회 학술대회
2001 .01
-
용매증발법에 의한 부피바카인 microsphere의 제조 및 평가
약학회지
2000 .01
-
Meeting the unmet: from traditional to cutting‑edge techniques for poly lactide and poly lactide‑co‑glycolide microparticle manufacturing
Journal of Pharmaceutical Investigation
2019 .01
-
파상풍에 대한 임상적 고찰
Annals of Surgical Treatment and Research
1991 .01
-
토끼 두개골 결손부의 골재생에 대한 poly(lactide-co-glycolide) (PLGA) 의 영향
Journal of Periodontal & Implant Science
2009 .01
-
Electrospun poly (lactic-co-glycolic acid)(PLGA) nanoparticles for controlled drug delivery system
대한약학회 학술대회
2003 .01
-
PLGA 종류와 담체의 형성 방법에 따른 인간의 조직공학적 연골형성
의공학회지
2002 .01
-
Characterization of Dexamethasone-eluting PLGA Films Coated on Capsular Tension Ring to Prevent Posterior Capsule Opacification
Biomolecules & Therapeutics(구 응용약물학회지)
2008 .01
-
Development of New Reverse Micellar Microencapsulation Technique to Load Water-Soluble Drug into PLGA Microspheres
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2005 .01
-
Poly(lactic acid)/poly(lactic‑co‑glycolic acid)‑based microparticles: an overview
Journal of Pharmaceutical Investigation
2019 .01
-
3차 군병원 응급실에 내원한 국군 병사들의 파상풍 항체의 정성적 조사
Journal of trauma and injury : JTI
2007 .01
-
구개부에 발생한 다형성 저등급 선암종의 치험례
대한구강악안면외과학회지
2011 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0