흰쥐에 있어서 PEG-헤모글로빈 SBI의 단회정맥투여 약물동태

신호철; 심희옥; 유승룡; 김종춘; 양승돈; 정문구

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자료유형: 학술저널

저자정보: 신호철 (한국화학연구소 안전성연구부 약물독성동태연구실) 심희옥 (한국화학연구소 안전성연구부 약물독성동태연구실) 유승룡 (한국화학연구소 안전성연구부 약물독성동태연구실) 김종춘 (한국화학연구소 안전성연구부 약물독성동태연구실) 양승돈 (한국화학연구소 안전성연구부 약물독성동태연구실) 정문구 (한국화학연구소 안전성연구부 약물독성동태연구실)

저널정보: 대한약학회 약학회지 약학회지 제44권 제3호

발행연도: 2000.1

수록면: 232 - 236 (5page)

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An intravenous pharmacokinetics for a new red cell substitute, PEG-hemoglobin SB1, was studied in SD rats. Total-hemoglobin and its metabolite methemoglobin in the plasma were determined using a spectrophotometer. The limit of quantitation was 0.01g/dL and the C.V for interday assay reproducibility was less than 6%. Upon intravenous administration of anticipated clinical dose, 10 ml(0.7 gHb)/kg, plasma concentration curve of total-hemoglobin was well described by one-compartment model. The $t_{\frac{1}{2}},{\;}CL_{t}$, Vd and $AUC^{0-48hr}$ were $8.23{\pm}0.96{\;}hr,{\;}0.06{\;}{\pm}{\;}0.01 {\;}dL/hr/kg,{\;}0.66{\pm}0.05{\;}dL/lg{\;}and{\;}13.6{\;}{\pm}{\;}1.01g{\cdot}hr/dL$, respectively, in male rats(n=5, $mean{\;}{\pm}{\;}SD$). Those parameters in female rats were $9.21{\;}\pm{\;}2.31{\;}hr,{\;}0.06{\;}{\pm}{\;}0.01{\;}dL/hr/kg,{\;}0.79{\pm}{\;}0.08{\;}dL/kg{\;}and{\;}13.0{\;}{\pm}{\;}2.36{\;}g{\cdot}hr/dL$, respectively. Similar kinetic profiles between males and females were also obtained from other parameters. Small amount of methemoglobin, an oxidative metabolite of SB1, was detected in the plasma of both sexes, where the $AUC^{0-48{\;}hr,m}$ and $t_{{\frac{1}{2}},m}$ were approximately $1.5{\;}g{\cdot}hr/dL$ and 20 hr, respectively. The present work provides a critical kinetic data for the effective clinical applications of PEG-hemoglobin SB1.

#PEG-hemoglobin SB1 #pharmacokinetics #rats

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