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논문 기본 정보

자료유형
학술저널
저자정보
이태업 (경산대학교 부속한방병원 내과학교실) 김진성 (Dept. of Oriental Medicine, Graduate School, Kyung Hee University) 윤상협 (Dept. of Oriental Medicine, Graduate School, Kyung Hee University) 류봉하 (Dept. of Oriental Medicine, Graduate School, Kyung Hee University) 박동원 (Dept. of Oriental Medicine, Graduate School, Kyung Hee University) 류기원 (Dept. of Oriental Medicine, Graduate School, Kyung Hee University)
저널정보
대한암한의학회 대한한방종양학회지 대한한방종양학회지 제6권 제1호
발행연도
2000.1
수록면
1 - 18 (18page)

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The present study was performed in order to evaluate the effects of the gamihyangsayukgunjatang on radioprotection and apoptosis in small intestines of mice after whole body irradiation. Two hundred forty mice were divided into 40 groups according to the radiation dose and the gamihyangsayukgunjatang treatment. The extracts of the herbal medicines were orally administered to each group differently before and/or after irradiation. The gamihyangsayukgunjatang treated groups were divided into 3 groups. Sample Ⅰ was the group treated with the gamihyangsayukgunjatang for 3 days before the radiation, sample Ⅱ was the group treated with the gamihyangsayukgunjatang for 3 days after the radiation. Sample Ⅲ was the group treated with the gamihyangsayukgunjatang for both 3 days before and after the radiation. To analyze the crypt survival, the micradony survival assay was used according to the Withers and Elind's method. To analyze the apptosis, the TUNEL assay was done. The results obtained are a follows : 1. From the microcolony survival assay, the gamihyangsayukgunjatang treated groups showed the radioprotective effect with a statistical significance(p<0.05), as compared to the control group. Comparing the radioprotective effect among the 3 groups, sample III was statistically more significant than sample I and II (p<0.05). Sample I showed no effect. In accordance with the research mentioned above, it is suggested that the radioprotective effect of the gamihyangsayukgunjatang is more useful for the treatment of the radiation injury rather that the prevention. 2. The results of the TUNEL assay showed that the apoptotic index in the gamihyangsayukgunjatang treated group was slightly decreased with no effectiveness, as compared to the control group. According to the above results, it could be suggested that the gamihyangsayukgujatang has a prominent protective effect in mice intestines against the radiation damage. However, the radioprotective effect does not seem to be related to inhibition of the apoptosis.

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