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논문 기본 정보

자료유형
학술저널
저자정보
Seo, Eun-Kyung (Department of Gynecology, Dong-A University) Kim, Kyoung-Sook (Faculty of Natural Resources and Life Science, Dong-A University) Lee, Tae-Kyun (Department of Gynecology, Dong-A University) Woo, Dae-Yoon (Department of Gynecology, Dong-A University) Kim, Cheorl-Ho (Department of Biochemistry and Molecular Biology, College of Oriental Medicine, Dongguk University) Lee, Young-Choon (Faculty of Natural Resources and Life Science, Dong-A University)
저널정보
경희한의학연구센터 International journal of oriental medicine : OM International journal of oriental medicine : OM 제1권 제2호
발행연도
2000.1
수록면
14 - 20 (7page)

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This study was designed to investigate the effect of dietary Platycodon grandiflorum on plasma glucose and lipid metabolism in $KK-A^y$ mice and STZ-induced diabetic rats. Both plasma triglyceride and plasma cholesterol levels in STZ-induced diabetic rats were significantly decreased by dietary Platycodon grandiflorum feeding for 4 weeks compared to those of control rats, but there were no marked differences in $KK-A^y$ mice. However, for plasma glucose values, Platycodon grandiflorum feeding resulted in a significant decrease in both STZ-induced diabetic rats and $KK-A^y$ mice. Also, dietary Platycodon grandiflorum slightly decreased the postprandial glucose level at 30 and 60 mins during oral glucose tolerance test in $KK-A^y$ mice. Although there was no statistical significance, the fasting plasma insulin levels of Platycodon grandiflorum dieted $KK-A^y$ mice tended to decrease when compared to that of control mice. Therefore, the present results suggested that dietary Platycodon grandiflorum may have a beneficial effect on preventing hypercholesterolemia and hyperlipidemia.

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