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논문 기본 정보

자료유형
학술저널
저자정보
하미애 (경남과학기술대학교 농학.한약자원학부) 김진우 (경남과학기술대학교 농학.한약자원학부) 이신우 (경남과학기술대학교 농학.한약자원학부) 전현식 (경남과학기술대학교 농학.한약자원학부) 조영손 (경남과학기술대학교 농학.한약자원학부) 신용욱 (경남과학기술대학교 농학.한약자원학부)
저널정보
대한본초학회 대한본초학회지(본초분과학회지) 대한본초학회지 제29권 제6호
발행연도
2014.1
수록면
165 - 173 (9page)

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Objectives : Platycodon Root is frequently used in traditional medicine to treat inflammatory diseases of the throat. The purpose of this study was to characterize the effect of the EtOH extract of fermented Platycodon grandiflorum on the ameliorative effects on the Antipruritic Effect of atopic dermatitis mouse model induced by compound 48/80 and ovalbumin (OVA)-induced allergic responses in mice. Methods : In the present study, we examined the anti allergic effect of Platycodon grandiflorum (PR) and its fermented production (FPR) in several mouse model. We measured acute ear edema in a mouse model caused by TPA and consecutively histological change of Ear tissue was observed by hematoxylin and eosin (H&E) staining. and also Scratching behaviors by compound 48/80 was investigated. The levels of allergic mediators such as immunoglobulin (Ig) E, and anti-oxidant markers such as SOD and MDA in the sera of OVA induced allergic mice were measured by enzyme-linked immunosorbent assay. Results : FPR inhibited compoud 48/80-induced scratching behavior in mice, as well as acetic acid-induced writhing in mice. The anti-scratching behavioral effect of FPR was more potent than PR. FPR extract significantly decreased the serum levels of IgE and MDA compared with those of OVA control group. Conclusions : These results indicate that Anti allergic effect of Platycodon grandiflorum is enhanced by fermentation with Saccharomyces cerevisae and FPR may be useful for protection from the itching reactions, which are IgE-mediated representative skin allergic diseases.

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