구개편도 및 인두편도에서 혈관내피성 접착분자의 발현에 관한 연구

조진희; 장한성; 원유성; 이수진; 윤희로; 서병도

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자료유형: 학술저널

저자정보: 조진희 (가톨릭대학교 의과대학 이비인후과학교실) 장한성 (가톨릭대학교 의과대학 이비인후과학교실) 원유성 (가톨릭대학교 의과대학 이비인후과학교실) 이수진 (가톨릭대학교 의과대학 이비인후과학교실) 윤희로 (가톨릭대학교 의과대학 이비인후과학교실) 서병도 (가톨릭대학교 의과대학 이비인후과학교실)

저널정보: 대한기관식도과학회 대한기관식도과학회지 대한기관식도과학회지 제5권 제2호

발행연도: 1999.1

수록면: 174 - 181 (8page)

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The palatine tonsils(tonsils) and pharyngeal tonsils(adenoids) are situated at the entrance of the respiratory and alimentary tracts and represent the first site of contact with a variety of microorganisms and other antigens present in food and inhaled air. They are known as lymphoid organs carrying out the function of cellular and humoral immunity, and so they form a local protective barrier. And the expression of the vascular endothelial adhesion molecules is known to play an important role for the inflammatory reaction in tonsils and adenoids as well as in other inflammatory tissues, by binding with the receptors on the surface of leukocytes. But although several scientific hypotheses on the role of these lympoid tissues have been suggested, their complete functions have remained unknown. The purpose of this study is to present an basic data of the knowledge on the immunologic physiology of the tonsils and adenoids and their role as active immunologic organs that reinforce the mucosal immunity of the entire upper aerodigestive tract. We examined 16 human tonsils and adenoids and the expression of three endothelial adhesion molecules, vascular endothelial adhesion molecule-1(VCAM-1), intracellular adhesion molecule-1(ICAM-1), and E-selection, in tissue sections using immunohistochemistry. We used the inferior turbinate mucosa obtained from 9 patients getting septal surgery as a control group. The expressions of vascular endothelial adhesion molecule-1(VCAM-1) and intracellular adhesion molecule-1 (ICAM-1) were significantly higher in the tonsils and adenoids. But respectively, there were no significant differences between the tonsils and adenoids. The expression of E-selection was significant higher in the tonsils, but not in the adenoids. We observed that tonsils and adenoids showed significantly higher expressions of vascular endothelial adhesion molecule-1(VCAM-1), intracellular adhesion molecule-1(ICAM-1), and E-selection (in the case of E-selection, only in the tonsils). We propose that these adhesion molecules play an important role for the immunologic reaction by the transendothelial migration of lymphocytes and binding with the receptors on the surface of leukocytes.

#구개편도 #인두편도 #혈관내피성 접착분자

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