지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
In order to formulate a controlled release system for oral drug delivery, the microcapsules were prepared in w/o emulsion containing cefaclor as a water-soluble model drug by th e method of interfacial polycondensation. Gelatin wis selected as a suitable polymer for interfacial polycondensation. Gelatin solution containing drug was emulsified in an organic phase under mechanical stirring. After emulsification, terephthaloyl chloride was added as cross linking agent, followed by mechanical stirring, washing and drying. Physical characteristics of microcapsules were investigated by optical microscopy, scanning electron microscopy and particle size analysis. Mean particle sizes of gelatin microcapsules were, in the range, of about 20~50 ${\mu}$m. The microcapsules were in good apperance with spherical shapes before washing, but were destroyed partially after washing and drying, even though some microcapsules were still maintained in their shapes. Contents of cefaclor in the microcapsules were calculated by UV spectrophotometry after 3 days extraction with pH 4 carbonate buffer solution. The effects of cross linking time. pH. concentration of cross-linking agent, and temperature on drug release kinetics have been discussed extensively.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
젤라틴-아리비아고무를 써서 製造한 인도메타신 마이크로캅셀의 용출 특성
약학회지
1984 .01
-
Retarded Dissolution of Ibuprofen in Gelatin Microcapsule by Cross-Linking with Glutaradehyde
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2006 .01
-
Coacervate microcapsules of vitamin U optimized by central composite design (CCD)
Journal of Pharmaceutical Investigation
2019 .01
-
Sodium salicylate 나일론 마이크로캅셀 제조에 미치는 Matrix의 영향
약학회지
1984 .01
-
Eudragit $RS^{\circledR}$를 이용한 지속 방출형 아스피린 마이크로캅셀의 제조 및 평가
약학회지
1988 .01
-
Characteristics of ethylcellulose microcapsules of sulfisoxazole
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
1982 .01
-
Microencapsulation of Isoprinosine with Ethylcellulose
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
1991 .01
-
Preparation of magnetic gelatin microspheres for the targeting of drugs
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
1986 .01
-
Synthesis of gelatin capped gold nanoparticles with variable gelatin concentration
대한치과재료학회 학술대회
2009 .11
-
Cross-Linked Starch Microspheres: Effect of Cross-Linking Condition on the Microsphere Characteristics
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2006 .01
-
W/O 에멀젼에 의한 chitosan microcapsule 및 microbead의 morphology와 팽윤성
대한화장품학회지
1995 .01
-
Modification and optimization of electrospun gelatin sheets by electron beam irradiation for soft tissue engineering
생체재료학회지
2017 .01
-
Comparison of the Wound Healing Effect of Cellulose and Gelatin: An In Vivo Study
Archives of plastic surgery : APS
2012 .01
-
Clinical and Microbiological Studies on the Effects of 10% Minocycline-HCl Loaded Microcapsules in the Treatment of Adult Periodontitis
대한임상약리학회 학술대회
1995 .01
-
Pectin-Gelatin Complex Coacervation 에 의한 Indomethacin의 Microencapsulation 에 관한 연구
약학회지
1989 .01
-
Nalidixic Acid의 Eudragit RL Microencapsulation에 관한 연구
약학회지
1990 .01
-
한국 초.중.고.대학생들에서 약물정보습득의 방법 및 약물오남용의 위험성에 대한 평가
약학회지
2013 .01
-
Bone Matrix Gelatin이 일차배양 골아세포의 DNA생합성에 미치는 영향
대한정형외과학회지
1992 .04
-
청소년의 약물남용 예방교육 요구도 조사
Child Health Nursing Research
2003 .01
-
Gelatin Gel의 점탄성에 관한 연구
약학회지
1981 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0