지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 1997.1
- 수록면
- 637 - 640 (4page)
이용수
초록· 키워드
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Raf-1, a cytoplasmic serine/threonine protein kinase, serves as a central intermediate in many signaling pathways in cell proliferation, differentiation, and development. In this study, we investigated that B-raf, Drosophila homolog of the human c-raf-1, is involved in ultraviolet (UV) responsive events by using hypomorphic mutant $D-raf^{c110}$ and Draf-lacZ transgenic fly. At first, effect of UV damage on the survival of wild-type and $D-raf^{C110}$ strains was examined. In terms of $1/LD_{50}$ value, the relative ratio of UV sensitivities of wild-type versus $D-raf^{C110}$ strain was 1 : 2.2. By using quantitative $\beta$-galactosidase activity analysis, transcriptional activity of the D-raf gene promoter was also examined in UV-irradiated Draf-lacZ transgenic larvae. UV irradiation increased the expression of lacZ reporter gene in Draf-lacZ transgenic fly. However, in $D-raf^{C110}$ strain the transcriptional activity of D-raf gene promoter by UV irradiation was extensively reduced. Results obtained in this study suggest that D-raf plays a role in UV response, leading to better survival of Drosophila to UV damage.
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Analysis of role of the D-raf in the UV-mediated signal transduction pathway
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Roles of Transcription Factor Binding Sites in the D-raf Promoter Region
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Transcriptional Regulation of the Drosophila raf Proto-oncogene
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형질전환 초파리를 이용한 Drosophila raf 유전자 발현조절영역에 존재하는 STAT결합부위의 역할에 관한 연구 ( Analysis of the Role of STAT Binding Site in the Drosophila raf Promoter Region Using Transgenic Flies )
생명과학회지
1999 .02
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Transcriptional Regulation of the Drosophila Proliferating Cell Nuclear Antigen Gene and raf Proto-oncogene by Ursolic Acid in Drosophila Cultured Kc Cells
Korean journal of biological sciences
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RKIP Downregulation Induces the HBx-Mediated Raf-1 Mitochondrial Translocation
Journal of Microbiology and Biotechnology
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Arabidopsis Raf-Like Kinase Raf10 Is a Regulatory Component of Core ABA Signaling
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미만형 위암에서 임상병리학적 인자와 Hsp70, BAG1과 Raf-1 발현간의 상관성
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2016 .01
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쥐 소뇌에 있어서 raf protein kinases 의 면역 세포 회복적 분포와 단백질 양상 ( Immunocytochemical distribution of raf protein kinases and protein pattern in rat cerebellum )
생명과학회지
1998 .02
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Screening of Transcriptional Regulator of the D-raf Proto-oncogene Using the Yeast One-hybrid System
Journal of Life Science
1999 .10
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Transcriptional Inhibition of the Drosophila raf and PCNA gene by the Homeodomain Protein Engrailed
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Regulation of the Drosophila Fascin by Raf Signaling
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2009 .07
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Regulation of the Drosophila raf and PCNA Gene Expression by the Homeodomain Protein, Ftz and Engrailed
한국동물학회 학술대회
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Establishment of Transgenic Drosophila Bearing Metallothionein-lacZ Fusion Gene and Its Practical Use
Korean journal of biological sciences
1998 .01
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Characterization of Expression of UV-Inducible Gene ( UV100 and UV150) in Caenorhabditis elegans
생명과학회지
2006 .07
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Establishment of Transgenic Drosophila Bearing Metallothionein-LacZ Fusion Genes
한국동물학회 학술대회
1996 .01
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Oxidative Stress-regulated Metallothionein Gene Expression by Analysis of MT-lacZ Transgenic Drosophila
한국동물학회 학술대회
1997 .01
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A role of mitochondrial membrane proteins in Drosophila blood cells against UV irradiation
한국생명과학회 심포지움
2004 .05
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2011 .12
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