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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 1998.1
- 수록면
- 117 - 122 (6page)
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초록· 키워드
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D-raf, a Drosophila homolog of the human c-raf-1, is known as a signal transducer in cell proliferation and differentiation. A previous study found that the D-raf gene expression is regulated by the DNA replication-related element (DRE)/DRE-binding factor (DREF) system. In this study, we found the sequences homologous to transcription factor C/EBP, MyoD, STAT and Myc recognition sites in the D-raf promoter. We have generated various base substitutional mutations in these recognition sites and subsequently examined their effects on D-raf promoter activity through transient CAT assays in Kc cells with reporter plasmids p5'-878DrafCAT carrying the mutations in these binding sites. Through gel mobility shift assay using nuclear extracts of Kc cells, we detected factors binding to these recognition sites. Our results show that transcription factor C/EBP, STAT and Myc binding sites in D-raf promoter region play a positive role in transcriptional regulation of the D-raf gene and the Myo D binding site plays a negative role.
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Transcriptional Regulation of the Drosophila Proliferating Cell Nuclear Antigen Gene and raf Proto-oncogene by Ursolic Acid in Drosophila Cultured Kc Cells
Korean journal of biological sciences
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raf Proto-oncogene is Involved in Ultraviolet Response in Drosophila
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형질전환 초파리를 이용한 Drosophila raf 유전자 발현조절영역에 존재하는 STAT결합부위의 역할에 관한 연구 ( Analysis of the Role of STAT Binding Site in the Drosophila raf Promoter Region Using Transgenic Flies )
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Journal of Microbiology and Biotechnology
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미만형 위암에서 임상병리학적 인자와 Hsp70, BAG1과 Raf-1 발현간의 상관성
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Analysis of role of the D-raf in the UV-mediated signal transduction pathway
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Transcriptional Regulation of the Drosophila raf Proto-oncogene
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1999 .01
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쥐 소뇌에 있어서 raf protein kinases 의 면역 세포 회복적 분포와 단백질 양상 ( Immunocytochemical distribution of raf protein kinases and protein pattern in rat cerebellum )
생명과학회지
1998 .02
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Screening of Transcriptional Regulator of the D-raf Proto-oncogene Using the Yeast One-hybrid System
Journal of Life Science
1999 .10
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Transcriptome analysis and promoter sequence studies on early adipogenesis in 3T3-L1 cells
Nutrition Research and Practice
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Transcriptome analysis and promoter sequence studies on early adipogenesis in 3T3-L1 cells
Nutrition Research and Practice
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Regulation of the Drosophila Fascin by Raf Signaling
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Transcriptional Inhibition of the Drosophila raf and PCNA gene by the Homeodomain Protein Engrailed
한국동물학회 학술대회
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Regulation of the Drosophila raf and PCNA Gene Expression by the Homeodomain Protein, Ftz and Engrailed
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C/EBP binding activity to site F of the rat GLUT2 glucose transporter gene promoter is attenuated by c-Jun in vitro
Experimental and Molecular Medicine
2002 .01
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Involvement of HB-EGF, the EGF Receptor, C-Raf, Mek-1, and Erk2 in Helicobacter pylori-Induced Gastrin Promoter Activation
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Role of a Novel Fur-Binding Site in Transcriptional Activation
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2009 .05
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Early growth response protein 1 acts as an activator of SOX18 promoter
Experimental and Molecular Medicine
2010 .01
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