지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 1997.1
- 수록면
- 317 - 321 (5page)
이용수
초록· 키워드
오류제보하기
Tau protein is one of the microtubule-associated proteins in the mammalian brain. In Alzheimer's disease, tau protein is immobilized in the somatodendritic compartment of certain nerve cells, where it forms a part of the paired helical filament (PHF). To understand the role of tau protein in the formation of PHF, a recombinant human tau protein expressed in Escherichia coli and five synthetic peptide fragments (peptide 1 to peptide 5), corresponding to the C-terminal region of tau protein, were prepared and their ability in self-assembly to form filamentous structures was examined. The recombinant human tau protein formed short rod-like structures in 0.1M MES buffer containing 1 mM $MgCI_2$, while a synthetic peptide fragment 1 containing 55 amino acid residues could assemble into a lot of long filamentous structures in water and particularly twisted helical structures in 0.1M MES buffer containing 1 mM $MgCI_2$. This suggests that the C-terminal region possesses a filament-forming ability and may be related to the formation of the helical structure by providing a powerful filament-forming driving force.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Failure Analysis of Filaments of Quadrupole Mass Spectrometer for Plasma Process Monitoring
Applied Science and Convergence Technology
2015 .09
-
Molecular Structure of Muscle Filaments Determined by Electron Microscopy
한국현미경학회지
2017 .01
-
Large-area imaging evolution of micro-scale configuration of conducting filaments in resistive switching materials using a light-emitting diode
한국진공학회 학술발표회초록집
2016 .02
-
Characterization of Luster Properties of Nylon 6 Hollow Filament Yarn Woven Fabric- Three-dimensional Simulation of Hollow Filament -
패션 비즈니스
2004 .01
-
A non-destructive study of the conducting filaments in resistive switching metal-oxides using superconducting proximity effect
한국진공학회 학술발표회초록집
2017 .02
이 논문의 저자 정보
최근 본 자료
댓글(0)
0