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자료유형
학술대회자료
저자정보
Lee, June-Woo (Central Research Laboratory, Il Yang Pharmaceutical Company, Ltd.) Jeong, Hoon (Central Research Laboratory, Il Yang Pharmaceutical Company, Ltd.) Han, Man-Deuk (Central Research Laboratory, Il Yang Pharmaceutical Company, Ltd.) Kim, Su-Ung (Central Research Laboratory, Il Yang Pharmaceutical Company, Ltd.) Lee, Seung-Yong (Central Research Laboratory, Il Yang Pharmaceutical Company, Ltd.) Kim, Kee-Nam (Central Research Laboratory, Il Yang Pharmaceutical Company, Ltd.) Chung, Sung-Kyun (Central Research Laboratory, Il Yang Pharmaceutical Company, Ltd.) Baek, Seong-Jin (Central Research Laboratory, Il Yang Pharmaceutical Company, Ltd.) Song, Jae-Jin (Central Research Laboratory, Il Yang Pharmaceutical Company, Ltd.) Kim, Yong-Seok (Central Research Laboratory, Il Yang Pharmaceutical Company, Ltd.) Kang, Sang-Mo (Department of Microbial Engineering, Kon-kuk univ.)
저널정보
한국응용약물학회 한국응용약물학회 춘계학술발표논문집 한국응용약물학회 1995년도 춘계학술대회
발행연도
1995.1
수록면
107 - 107 (1page)

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The purpose of this study was to observe the effects of the polysaccharide(G009) obtained from liquid cultured Ganoderma lucidum IY009 on the lipidperoxidation in rat liver microsome. It is well known that the polysaccharide of G. lucidum have the hepatoprotective activity, antitumor activity etc., which was thought to have the relationship to anti-lipidperoxidation. In order to the estimate the effects of anti-lipidperoxidation of the polysaccharide obtained from G. lucidum IY009, enzymatic and nonenzymatic reaction were performed, in vitro, in rat liver microsome. In enzymatic lipid peroxidation reaction by ADP/FeCl$_3$/NADPH and $CCl_4$/NADPH, G009(1mg/ml) inhibited 77.4%, 39.4%, respectively, and the nonenzymatic reaction strongly exhibited 97.4% inhibition. And also, in enzymatic and nonenzymatic inducers treated with G009, the formation of MDA was progressively greater decreased by raising G009 concentration. These results suggest that anti-lipidperoxidation by G009 treatment may be play an important part in liver protection action.

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