Enhancing Effects of Indole-3-carbinol on Hepatocarcinogenesis and Thyroid Tumorigenesis in a Rat Multi-Organ Carcinogenesis Model

Kim, Dae-Joong; Han, Beom-Seok; Ahn, Byeong-Woo; Kim, Chang-Ok; Choi, Kwang-Sik; Lee, Joon-Sup

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자료유형: 학술대회자료

저자정보: Kim, Dae-Joong (Dept. of Pathol., Nat'l. Inst. Safety Res.) Han, Beom-Seok (Dept. of Pathol., Nat'l. Inst. Safety Res.) Ahn, Byeong-Woo (Dept. of Pathol., Nat'l. Inst. Safety Res.) Kim, Chang-Ok (Dept. of Pathol., Nat'l. Inst. Safety Res.) Choi, Kwang-Sik (Dept. of Pathol., Nat'l. Inst. Safety Res.) Lee, Joon-Sup (Coll. of Vet. Med., Seoul Nat'l. Univ.)

저널정보: 한국응용약물학회 한국응용약물학회 춘계학술발표논문집 한국응용약물학회 1994년도 춘계학술대회 and 제3회 신약개발 연구발표회

발행연도: 1994.1

수록면: 339 - 339 (1page)

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It has been reported that Indole-3-carbinol (I3C), a naturally occurring compound In cruclferous vegetables, exerts anticarcinogenic activity In several organs In rodents. The modifying effects of I3C were therefore assessed uging a rat multi-organ carcinogenesis model. A total of 100 male Sprague-Dawley rats were divided Into 3 groups. Animals of groups 1 and 2 were sequentially treated with diethylnitrosamine (DEN; 100 mg/kg b.w., i.p.), N-methylnitrosourea (NNU; 20 mg/kg b.w., 4 times for 2 weeks, i.p), and dihydroxy-di-N-propylnitrosauine (DHPN; 0.1% In d.w. for 2 weeks) for 4 weeks (DMD treatment). Animals of groups 1 and 3 were given the diet of 0.25% I3C for 20 weeks after DMD initiation and then were given basal diet for 28 weeks. All animals were sacrificed at week 24 and 52, respectively. I3C has been clearly demonstrated promoting effects on the development of glutathione S-transferase placental form (GST-P) positive hepatic foci at 24 weeks of the experiment. And I3C also exerted promoting potential In the hepatocellular adenoma (4/14; 29%) and the adenoma (7/14; 50%) of the thyroid gland at 52 weeks of the experiment. Therefore, I3C may promote hepatocarcinogenesis and thyroid tumorigenesis in the rat multi-organ carcinogenesis model.

#Indole-3carbinol #I3C) #Hepatocarcinogenesis #DMD treatment #$GST-P^{+}$ hepatic foci #rate multi-organ carcinogenesis model

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