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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.12
- 수록면
- 339 - 343 (5page)
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초록· 키워드
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Indole-3-carbinol (I3C) found in various cruciferous vegetables has been shown to exert anti-carcinogenic activity in several target organs. Our study was conducted to assess the modifying effect of I3C on the development of colon tumor induced by azoxymethane (AOM). Eighty-seven male F344 rats were divided into 5 groups and were treated with AOM followed by I3C 100 or 300 ppm, AOM alone, I3C alone, and non-treatment, respectively. The animals were subcutaneously injected with AOM. Then diet containing I3C were fed to the rats for 37 weeks. All rats were sacrificed at 40 weeks. Liver and kidney weights of rats treated with I3C at doses of 100 or 300 ppm were significantly increased compared to those of the control group. Colonic tumor incidence and multiplicity of rats treated with I3C at doses of 100 and 300 ppm were not significant compared to those of AOM alone group. In the pathological examination, most of tumors were classified with adenoma and adenocarcinoma in the small and large intestine. These results demonstrated that I3C may have not chemopreventive effect on the rat colon carcinogenesis.
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감사의 글
참고문헌
참고문헌 (24)
참고문헌 신청
Barrett, J.E. / 1998 / Protective effects of cruciferous seed meals and hulls against colon cancer in mice / Cancer Lett. 127(1-2):83~88
Broadbent, T.A. / 1998 / The chemistry and phamacology of indole-3-carbinol (indole-3-methanol) and 3-(methoxymethyl)indole / Curr. Med. Chem. 5(6):337~352
Dashwood, R.H. / 2003 / The disposition and metabolism of 2-amino-3-methy- limidazo-[4,5-f]quinoline in the F344 rat at high versus low doses of indole-3-carbinol / Food Chem. Toxicol. 41(8):1185~1192
Dashwood, R.H. / 1991 / Promotion of aflatoxin B1 carcinogenesis by the natural tumor modulator indole-3-carbinol: influenceofdose, duration, and intermittent exposure on indole-3-carbinol promotional potency / Cancer Res. 51(9):2362~2365
Guo, D. / 1995 / Protection by chlorophyllin and indole-3-carbinol against 2-amino-1-methyl-6 -phenylimidazo[4,5-b]pyridine (PhIP)-induced DNA adducts and colonic aberrant crypts in the F344 rat / Carcinogenesis 16(12):2931~2937
Broadbent, T.A. / 1998 / The chemistry and phamacology of indole-3-carbinol (indole-3-methanol) and 3-(methoxymethyl)indole / Curr. Med. Chem. 5(6):337~352
Dashwood, R.H. / 2003 / The disposition and metabolism of 2-amino-3-methy- limidazo-[4,5-f]quinoline in the F344 rat at high versus low doses of indole-3-carbinol / Food Chem. Toxicol. 41(8):1185~1192
Dashwood, R.H. / 1991 / Promotion of aflatoxin B1 carcinogenesis by the natural tumor modulator indole-3-carbinol: influenceofdose, duration, and intermittent exposure on indole-3-carbinol promotional potency / Cancer Res. 51(9):2362~2365
Guo, D. / 1995 / Protection by chlorophyllin and indole-3-carbinol against 2-amino-1-methyl-6 -phenylimidazo[4,5-b]pyridine (PhIP)-induced DNA adducts and colonic aberrant crypts in the F344 rat / Carcinogenesis 16(12):2931~2937
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P-18. Enhancing Effects of Indole-3-carbinol on Hepatocarcinogenesis and Thyroid Tumorigenesis in a Rat Multi-Organ Carcinogenesis Model
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Effects of Zinc on Colon Carcinogenesis Induced by Azoxymethane and Dextran Sodium Sulfate in Iron-overloaded Mice
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Nabag (Zizyphus spina-christi) Extract Prevents Aberrant Crypt Foci Development in Colons of Azoxymethane-Treated Rats by Abrogating Oxidative Stress and inducing Apoptosis
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Effect of Luteolin on the Levels of Glycoproteins During Azoxymethane-induced Colon Carcinogenesis in Mice
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Effect of Phytic Acid on the Formation of Colonic Aberrant Crypt Foci induced by Azoxymethane in Fe-overloaded Mice
Laboratory Animal Research
2009 .03
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Enhancing Effects of Indole-3-carbinol on Hepatocarcinogenesis and Thyroid Tumorigenesis in a Rat Multi-Organ Carcinogenesis Model
한국응용약물학회 춘계학술발표논문집
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UCI(KEPA) : I410-ECN-0101-2012-510-003862917