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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 1993.1
- 수록면
- 72 - 72 (1page)
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Chan'su the dried toad venom preparation, has been used for centuries as a cardiotonic a local anesthetic and in the treatment of ecphyma. Bufadienol ides are major effective components of Chan'so. Their pharmacological activities have been studies to date. However, their pharmacokinetic and metabolism have not been studied. Considering variously divergent pharmacological actions of bufadienolides we decided to examine their metabolism and their other biological activites. We isolated and purified various components of bufadienolides. Cinobufagin and bufalin are prominent components. Firstly we examined metabolism of cinobufagin and found that this compound was extensively metabolized into various metabolites by mixed-function oxidase and deacetylase.
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