지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Alkyl-phenylthionocarbamates already have been investigated as anthelmintics. Especially ethyl-phenylthionocarbamate is noted for its anthelmintic action. Author studied methods for synthesizing Alkyl-phenylthionocarbamates, Alkyl-p-phenetyl thionocarbamates, Alkyl-cyclohexylthionocarbamates, 5 kinds for each. For alkyl radical $-CH_{3}$, $-C_{2}H_{5}$, -n-propyl, -isobuthyl, -n-buthyl, being chosen. Compounds VIII, X, XIII, XIV, and XV are new compounds. At the sametime author prepared 4 kinds of Arylthionocarbamates, among which XVII, and XIX being new compounds. (Table I) The anthelmintic action of these thionocarbamates has been examined through kymographic records indicating the action of neuromuscular preparation of Eisenia foetida Savigny in the various concentration fo above compounds: -Trendelenburg method. Santonine as the criterion of the estimation. (Table. II) 1. Compounds I-X could be prepared by method A or method B. method A in sealed tube brought on better yield and purity. 2. Compounds XI-XV couldn't be prepared by method A but by method B. 3. Arylthionocarbamates XVI, XVII, XVIII, and XIX couldn't be prepared by method A or method B but by method C. 4. Analyzed N. contained in all compounds. Analyzed C.H. and N. contained in unknown compounds, VIII, X, XIII, XIV, XV, XVII, and XIX. 5. Examination of anthelmintic action has been done under the advice of Prof. J.S.Oh medical college, Seoul Nat. University. 6. Compounds VI-X showed little action. 7. Compounds XVI-XIX showed almost no action. 8. Compounds XI-XV showed stronger action than compounds I-V, which was reported already as a usable anthelmintics. 9. Compounds XI, XII, XIII and XIV showed strongest actions, stronger than santonine as recorded on kymographion of the Trendelenburg method. Provided that, the toxity of these compounds found mild enough for human system, these compounds will serve as anthelmintics of greater powers than compounds I-V. 10. In Alkylthionocarbamates, R'NH-radical more influence on the anthelmintic action than ester radical(-OR).
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
The Antitumor Potentials of Benzimidazole Anthelmintics as Repurposing Drugs
Immune Network
2020 .08
-
요꼬가와 吸蟲症에 대한 여러가지 藥劑의 驅蟲効果
Parasites, Hosts and Diseases
1978 .12
-
우무가사리(Gelidium amansii)의 구충성분에 대하여(제 1 보)
약학회지
1962 .01
-
New Drug Development Research using Diversity of Compounds
대한약학회 학술대회
2002 .01
-
Biotransformation of Ginsenoside Rb1 to Prosapogenins, Gypenoside XVII, Ginsenoside Rd, Ginsenoside F2, and Compound K by Leuconostoc mesenteroides DC102
Journal of Ginseng Research
2011 .09
-
Anthelmintic activity of $Clerodendrum$ $viscosum$
Oriental pharmacy and experimental medicine
2011 .01
-
Design and Combonatorial Synthesis of Selenoflavonoids and Indole Compounds for Neuroprotective Drug
대한약학회 학술대회
2003 .01
-
Pharmacokinetics of ginsenoside Rb1 and its metabolite compound K after oral administration of Korean Red Ginseng extract
Journal of Ginseng Research
2013 .10
-
Synthesis and Three-dimensional Qualitative Structure Selectivity Relationship of 3,5-Disubstituted-2,4- Thiazolidinedione Derivatives As COX2 Inhibitors
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2007 .01
-
선충류 감염에 대한 구충제 사용의 최근 진전
Infection and Chemotherapy
2011 .01
-
한국 Streptomyces SP.로부터 분리한 방향족 화합물과 지질 화합물의 세포독성 연구
The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology
1997 .01
-
Diversity of compounds in Korea Chemical Bank
대한약학회 학술대회
2002 .01
-
Structural Features of Polyphenolic Compounds in Their NO Inhibitory Activities
Biomolecules & Therapeutics(구 응용약물학회지)
2009 .01
-
구충생약 - 조충약을 중심으로
약학회지
1975 .01
-
역대 한의학 문헌의 고증(I)(XIV~XV) 275~321
한국한의학연구원 연구보고서
1996 .10
이 논문의 저자 정보
최근 본 자료
댓글(0)
0