The accuracy of sentinel node biopsy by <SUP>99m</SUP>Tc-sodium phytate in patients with pancreatic cancer

Ramin Sadeghi; Mohsen Aliakbarian; Hamed Shayegani; Bahram Memar; Vahid Reza Dabbagh

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저자정보: Ramin Sadeghi (Mashhad University of Medical Sciences) Mohsen Aliakbarian (Mashhad University of Medical Sciences) Hamed Shayegani (Mashhad University of Medical Sciences) Bahram Memar (Mashhad University of Medical Sciences) Vahid Reza Dabbagh (Mashhad University of Medical Sciences)

저널정보: 한국간담췌외과학회 Annals of Hepato-Biliary-Pancreatic Surgery 한국간담췌외과학회지 제24권 제3호

발행연도: 2020.8

수록면: 277 - 282 (6page)

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Backgrounds/Aims: Pancreaticoduodenectomy is the only potentially curative treatment for pancreatic cancer. The identification of the first nodal drainage site (sentinel node) may improve the detection of metastatic nodes and can contribute to a less invasive surgery. We aimed to determine the accuracy of sentinel node mapping in patients with pancreatic cancer using intraoperative radiotracer injection technique. Methods: At surgical exposure, peritumoral injection of 0.4-0.5 mci/0.5 ml of 99mTc- sodium phytate was performed. After tumor resection, sentinel nodes were investigated in the most common areas using a hand-held gamma probe. Any lymph node with in vivo count twice the background was considered as sentinel node, thus, it was removed and sent for pathological assessment. Then a standard lymph node dissection was performed for all patients. Results: Fourteen patients with cancer in the head of the pancreas were included in this study. Overall, 180 lymph nodes were harvested with a mean of 11.6±4.7 lymph nodes per patient. In eight patients, at least one sentinel node could be identified (detection rate about 64%). False negative rate of the study was 3/5 (60%). Conclusions: Our study revealed insufficient diagnostic accuracy and high false negative rate for sentinel lymph node mapping with 99mTc- sodium phytate in pancreatic cancer.

#Sentinel lymph node #Pancreatic neoplasms #Pancreaticoduodenectomy #Lymph node excision

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