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- 충북대학교 동물의학연구소 Journal of Biomedical and Translational Research Journal of Biomedical and Translational Research 제21권 제2호
- 발행연도
- 2020.1
- 수록면
- 72 - 78 (7page)
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Carcass grade primarily depends on marbling of intramuscular fat, which is associated with the texture and tenderness of beef. Accordingly, various economical molecular tests for high intramuscular fat in beef have been attempted. Especially, Hanwoo (Korean Cattle) intramuscular fat has higher levels of monounsaturated fatty acids than that in the beef of other cattle. Intramuscular fats are associated with levels of lipid metabolic genes in the liver transcriptome. Therefore, hepatic triglyceride synthesis can considerably increase intramuscular fat. To investigate the relationship between hepatic lipogenesis and carcass grade, we analyzed 52 Hanwoo liver samples from domestic farms, and evaluated lipid levels and transcript levels of glucose and lipid metabolism-related genes according to carcass grade. Oil-Red-O staining revealed fatty livers in high carcass grades. Moreover, we found significantly higher levels of mRNA for lipogenesis, glycolysis, and triglyceride synthesis genes in high carcass grade livers. Importantly, progesterone receptor membrane component 1 (Pgrmc1) levels were significantly lower in high carcass grade livers. As Pgrmc1 suppression is correlated with induction of de novo lipogenesis (DNL) and glycolysis genes, it has a diagnostic impact for high carcass grades. These results could be used for genetic improvements in carcass grades of cattle. More importantly, as Pgrmc1 can be detected in blood peripheral nucleated cells, it also has value for rapid blood diagnosis.
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참고문헌 (25)
참고문헌 신청
Polkinghorne RJ / 2010 / Meat standards and grading : a world view / Meat Sci 86:227~235
Joo ST / 2017 / Characteristics of Hanwoo cattle and health implications of consuming highly marbled Hanwoo beef / Meat Sci 32:45~51
이승환 / 2014 / Hanwoo cattle: origin, domestication, breeding strategies and genomic selection / 한국축산학회지 56(1):1~8
황영화 / 2016 / Fatty Acid Profiles of Ten Muscles from High and Low Marbled (Quality Grade 1++ and 2) Hanwoo Steers / 한국축산식품학회지 36(5):679~688
Ruiz R / 2014 / Sterol regulatory element-binding protein-1(SREBP-1)is required to regulate glycogen synthesis and gluconeogenic gene expression in mouse liver / J Biol Chem 289:5510~5517
Joo ST / 2017 / Characteristics of Hanwoo cattle and health implications of consuming highly marbled Hanwoo beef / Meat Sci 32:45~51
이승환 / 2014 / Hanwoo cattle: origin, domestication, breeding strategies and genomic selection / 한국축산학회지 56(1):1~8
황영화 / 2016 / Fatty Acid Profiles of Ten Muscles from High and Low Marbled (Quality Grade 1++ and 2) Hanwoo Steers / 한국축산식품학회지 36(5):679~688
Ruiz R / 2014 / Sterol regulatory element-binding protein-1(SREBP-1)is required to regulate glycogen synthesis and gluconeogenic gene expression in mouse liver / J Biol Chem 289:5510~5517
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