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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 충북대학교 동물의학연구소 Journal of Biomedical and Translational Research Journal of Biomedical and Translational Research 제21권 제1호
- 발행연도
- 2020.1
- 수록면
- 30 - 37 (8page)
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초록· 키워드
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Artemisia annua (AA) is a well-known as a source of antimalarial drug (artemisinin), which also has been traditionally used as an antipyretic and hemostatic agent in Korea and China. In preclinical effective study, a water extract of Artemisia annua (WEAA) ameliorated weight gain and hepatic lipid accumulation in high-fat diet-fed mice. The plasma levels of triglyceride, AST, and ALT were reduced in the WEAA-treated group. Based on these results, the safety of WEAA as a functional ingredient for liver health was evaluated in this repeated dose oral toxicity study before the clinical trial. Sprague- Dawley (SD) rats were treated by gavage with 20 times (1,000 mg/kg) more than the effective dose for 13 weeks. All rats had survived at the end of the study, and there were no changes indicating obviously abnormal clinical sign and behavior. The treatment of WEAA were also observed no obvious toxicities in the body weights, urine, hematological, serum biochemical, ophthalmic and histopathological examinations. Based on the results of this study, the NOAEL (no-observed-adverse-effect level) of WEAA in SD rats was estimated to be 1,000 mg/kg. In conclusion, WEAA could be used as a safe functional ingredient for the improvement of liver health in individuals with hepatic diseases including nonalcoholic steatohepatitis.
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참고문헌 (20)
참고문헌 신청
Iranshahi M / 2007 / Detection of sesquiterpene lactones in ten Artemisia species population of Khorasan provinces / Iran J Basic Med Sci 10:183~188
Watson LE / 2002 / Molecular phylogeny of subtribe Artemisiinae(Asteraceae), including Artemisia and its allied and segregate genera / BMC Evol Biol 2:17
김완수 / 2015 / Anti-inflammatory, Antioxidant and Antimicrobial Effects of Artemisinin Extracts from Artemisia annua L. / The Korean Journal of Physiology & Pharmacology 19(1):21~27
이정훈 / 2013 / 한국산 개똥쑥의 재배특성 및 수확시기에 따른 Artemisinin의 함량변이 / 한국약용작물학회지 21(6):433~438
이정훈 / 2010 / 한국산 개똥쑥의 작물학적 특성 / 한국약용작물학회지 18(1):46~50
Watson LE / 2002 / Molecular phylogeny of subtribe Artemisiinae(Asteraceae), including Artemisia and its allied and segregate genera / BMC Evol Biol 2:17
김완수 / 2015 / Anti-inflammatory, Antioxidant and Antimicrobial Effects of Artemisinin Extracts from Artemisia annua L. / The Korean Journal of Physiology & Pharmacology 19(1):21~27
이정훈 / 2013 / 한국산 개똥쑥의 재배특성 및 수확시기에 따른 Artemisinin의 함량변이 / 한국약용작물학회지 21(6):433~438
이정훈 / 2010 / 한국산 개똥쑥의 작물학적 특성 / 한국약용작물학회지 18(1):46~50
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