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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 충북대학교 동물의학연구소 Journal of Biomedical and Translational Research Journal of Biomedical and Translational Research 제20권 제4호
- 발행연도
- 2019.1
- 수록면
- 91 - 98 (8page)
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초록· 키워드
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This study aimed to examine the effect of a mild elevation in serum cholesterol level in a porcine coronary overstretch restenosis model using a balloon angioplasty catheter or drug-eluting coronary stent. Pigs were divided into two groups and were fed a commercial normal diet (CND, n = 4) or a high-fat diet (HFD, n = 4) for 5 weeks. Coronary overstretch injury by balloon angioplasty or stent implantation was induced in the left anterior descending and left circumflex artery after 1 week of feeding. Histopathological analysis was performed at 4 weeks after coronary injury. During the experiment, the total cholesterol level in the HFD group increased by approximately 44.9% (from 65.9 ± 3.21 mg/dL at baseline to 95.5 ± 9.94 mg/dL at 5 weeks). The lumen area in the CND group was reduced in comparison with that in the HFD group after balloon angioplasty. After stent implantation, the injury score showed no significant difference. There were significant differences in the neointimal area (2.7 ± 0.33 mm2 in the CND group vs. 3.3 ± 0.34 mm2 in the HFD group, p<0.05), lumen area (2.6 ± 0.54 mm2 in the CND group vs. 2.0 ± 0.33 mm2 in the HFD group, p<0.05), and percent area stenosis (52.0 ± 7.96% in the CND group vs. 62.4 ± 5.15% in the HFD group, p<0.05). Body weight change was not different between the two groups. Increased serum cholesterol level activated vascular smooth muscle cell proliferation in the porcine coronary overstretch model.
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등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
Low Wang CC / 2016 / Clinical Update : cardiovascular disease in diabetes mellitus : atherosclerotic cardiovascular disease and heart failure in type 2diabetes mellitus-mechanisms, management, and clinical considerations / Circulation 133:2459~2502
Tahir H / 2015 / An in silico study on the role of smooth muscle cell migration in neointimal formation after coronary stenting / J R Soc Interface 12:20150358
Theilmeier G / 2002 / Hypercholesterolemia impairs vascular remodelling after porcine coronary angioplasty / Cardiovasc Res 55:385~395
Weidinger FF / 1991 / Hypercholesterolemia enhances macrophage recruitment and dysfunction of regenerated endothelium after balloon injury of the rabbit iliac artery / Circulation 84:755~767
Schwartz RS / 1992 / Restenosis and the proportional neointimal response to coronary artery injury : results in a porcine model / J Am Coll Cardiol 19:267~274
Tahir H / 2015 / An in silico study on the role of smooth muscle cell migration in neointimal formation after coronary stenting / J R Soc Interface 12:20150358
Theilmeier G / 2002 / Hypercholesterolemia impairs vascular remodelling after porcine coronary angioplasty / Cardiovasc Res 55:385~395
Weidinger FF / 1991 / Hypercholesterolemia enhances macrophage recruitment and dysfunction of regenerated endothelium after balloon injury of the rabbit iliac artery / Circulation 84:755~767
Schwartz RS / 1992 / Restenosis and the proportional neointimal response to coronary artery injury : results in a porcine model / J Am Coll Cardiol 19:267~274
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