지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 365 - 376 (12page)
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초록· 키워드
오류제보하기
Nonalcoholic fatty liver is a type of fatty liver in which fat accumulates in the liver without alcohol. In the accumulation, Nrf1 and miR-378 genes play very important role, so called negative feedback loop, in which the two genes suppress the other’s production. In other words, Nrf1 activates fatty acid oxidation which promotes fat consumption in the liver, while miR-378 deactivates fatty acid oxidation. Thus, both genes regulate nonalcoholic fatty liver. In this paper, the negative feedback loop of Nrf1 and miR-378 are ex- pressed by a system of ordinary differential equations. And, bifurcation simulation shows the change in the amount of each gene with significant parameter range changes. Bifurcation simulation has also used to deter- mine the thresholds for transit between disease and steady state.
목차
등록된 정보가 없습니다.
참고문헌 (17)
참고문헌 신청
William W. Hager / 1988 / Applied numerical linear algebra :239
Liss / 2017 / PPARs and nonalcoholic fatty liver disease / Biochimie 136:65~74
G.Faye / 2011 / An introduction to bifurcation theory / NeuroMathComp Laboratory, INRIA, CNRS, ENS Paris
D.Jordan / 2007 / Nonlinear ordinary differential equations: an introduction for scien-tists and engineers, Vol. 10 / Oxford University Press
B.P.Ingalls / 2013 / Mathematical modeling in systems biology: an introduction / MIT press
Liss / 2017 / PPARs and nonalcoholic fatty liver disease / Biochimie 136:65~74
G.Faye / 2011 / An introduction to bifurcation theory / NeuroMathComp Laboratory, INRIA, CNRS, ENS Paris
D.Jordan / 2007 / Nonlinear ordinary differential equations: an introduction for scien-tists and engineers, Vol. 10 / Oxford University Press
B.P.Ingalls / 2013 / Mathematical modeling in systems biology: an introduction / MIT press
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