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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 679 - 686 (8page)
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Purpose: Statins, metformin, angiotensin-converting enzyme (ACE) inhibitors, and angiotensin receptor blockers (ARBs) havebeen suggested for treating age-related macular degeneration (AMD) due to their pleiotropic effects. Therefore, we investigatedwhether these drugs prevent AMD. Materials and Methods: We conducted a nested case-control study using the Korean National Health Insurance Service database. Using risk-set sampling of age, sex, cohort entry date, and follow-up duration, we identified incident patients with AMD and10 matching controls in cohorts with diabetes mellitus or cardiovascular diseases. Exposure was assessed within one year beforethe index date using patient prescription records. We conducted conditional logistic regression to estimate the odds ratios (ORs)and 95% confidence intervals (CIs) to evaluate the association between cardiovascular medications and AMD. Results: Our study included 2330 cases and 23278 controls from a cohort of 231274 patients. The ORs (95% CI) for AMD occurrencein users prescribed with statins, metformin, ACE inhibitors, and ARBs were 1.12 (0.94–1.32), 1.15 (0.91–1.45), 0.90 (0.61–1.34), and 1.21 (1.05–1.39), respectively. A duration-response was not observed. Conclusion: Statins, metformin, ACE inhibitors, and ARBs did not inhibit AMD in elderly patients. The absence of a duration-responsesupports the lack of a causal relationship.
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참고문헌 (27)
참고문헌 신청
Congdon NG / 2003 / Important causes of visual impairment in the world today / JAMA 290:2057~2060
Colijn JM / 2017 / Prevalence of age-related macular degeneration in Europe : the past and the future / Ophthalmology 124:1753~1763
Schaumberg DA / 2007 / High-sensitivity C-reactive protein, other markers of inflammation, and the incidence of macular degeneration in women / Arch Ophthalmol 125:300~305
Smith BT / 2007 / Treatment of neovascular agerelated macular degeneration: past, present and future directions / Curr Opin Ophthalmol 18:240~244
Snow KK / 1999 / Do age-related macular degeneration and cardiovascular disease share common antecedents? / Ophthalmic Epidemiol 6:125~143
Colijn JM / 2017 / Prevalence of age-related macular degeneration in Europe : the past and the future / Ophthalmology 124:1753~1763
Schaumberg DA / 2007 / High-sensitivity C-reactive protein, other markers of inflammation, and the incidence of macular degeneration in women / Arch Ophthalmol 125:300~305
Smith BT / 2007 / Treatment of neovascular agerelated macular degeneration: past, present and future directions / Curr Opin Ophthalmol 18:240~244
Snow KK / 1999 / Do age-related macular degeneration and cardiovascular disease share common antecedents? / Ophthalmic Epidemiol 6:125~143
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