지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 208 - 215 (8page)
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초록· 키워드
오류제보하기
Purpose: Despite morbidities and fatalities, nationwide epidemiologic data for severe cutaneous adverse reactions (SCARs), includingStevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug reaction with eosinophilia and systemicsymptoms (DRESS), are not widely available. We aimed to investigate SCAR epidemiology over the last two decades in Korea. Materials and Methods: We analyzed individual case safety reports (ICSRs) of SCARs in the Korea Adverse Event Reporting Systemfrom 1988 to 2013. Administered drugs, demographic profiles, and causality assessment according to the World Health Organization-Uppsala Monitoring Center system were analyzed. Results: A total of 755 SCAR cases (508 SJS/TEN, 247 DRESS) were reported. The number of SCAR ICSRs has been increasingwith increasing ICSRs for overall adverse drug events. Since 2010, the number of SCAR ICSRs has increased up to 100 cases/year. Allopurinol was the most common causative drug (SJS/TEN: 10.2%; DRESS: 11.3%; SCAR ICSRs: 10.6%), followed by carbamazepine(SJS/TEN: 8.7%; DRESS: 9.7%; SCAR ICSRs: 8.6%). Regarding drug groups, antiepileptics (19.5%) and antibiotics for systemicuse (12.7%) were common causative drug groups. Twenty SCAR-related deaths were recorded. Antibacterials were the mostcommon causes of deaths (8 cases), followed by antiepileptics (5 cases). The potential risk of SCARs was not specified in the druginformation leaflet for 40.2% of drugs causing SJS/TEN and 82.5% causing DRESS syndrome in Korea. Conclusion: The number of SCAR ICSRs has increased rapidly with recent active pharmacovigilance programs in Korea. Allopurinoland antiepileptics are the most common individual and categorical causative agents, respectively.
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참고문헌 (27)
참고문헌 신청
1972 / International drug monitoring: the role of national centres. Report of a WHO meeting
Lazarou J / 1998 / Incidence of adverse drug reactions in hospitalized patients : a meta-analysis of prospective studies / JAMA 279:1200~1205
2015 / GBD 2013 Mortality and Causes of Death Collaborators. Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013 / Lancet 385:117~171
Swanson L / 2015 / Approach to the patient with a suspected cutaneous adverse drug reaction / Med Clin North Am 99:1337~1348
Yang MS / 2013 / Clinical features and prognostic factors in severe cutaneous drug reactions / Int Arch Allergy Immunol 162:346~354
Lazarou J / 1998 / Incidence of adverse drug reactions in hospitalized patients : a meta-analysis of prospective studies / JAMA 279:1200~1205
2015 / GBD 2013 Mortality and Causes of Death Collaborators. Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013 / Lancet 385:117~171
Swanson L / 2015 / Approach to the patient with a suspected cutaneous adverse drug reaction / Med Clin North Am 99:1337~1348
Yang MS / 2013 / Clinical features and prognostic factors in severe cutaneous drug reactions / Int Arch Allergy Immunol 162:346~354
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