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초록· 키워드
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Orthopaedics owes its current status of advanced care to the development of biomaterial science more than any other clinical medical specialty. The purpose of this brief review is to introduce the history and present status of biomaterials in orthopaedic field and cast a perspective on the future use of biomaterials to treat musculoskeletal disorders with particular emphasis on immune modulation. While the biomaterials in orthopaedics started from inert materials to replace the function and structure of hard tissue such as bone and cartilage, regenerative medicine will play a greater role in preventing the traumatic loss of tissues, as well as in the earlier stages of diseases. The understanding and modulation of immune response to biomaterials will further lead to the better incorporation of implants into host tissue or the near-perfect regeneration of host tissue.
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참고문헌 (30)
참고문헌 신청
Williams DF / 2009 / On the nature of biomaterials / Biomaterials 30:5897~5909
Sridharan R / 2015 / Biomaterial based modulation of macrophage polarization : a review and suggested design principles / Mater Today 18:313~325
Fukazawa T / 2009 / Suppression of the immune response potentiates tadpole tail regeneration during the refractory period / Development 136:2323~2327
Mescher AL / 2005 / Regenerative medicine I / Springer :39~66
Mescher AL / 2013 / Changes in the inflammatory response to injury and its resolution during the loss of regenerative capacity in developing Xenopus limbs / PLoS One 8:e80477
Sridharan R / 2015 / Biomaterial based modulation of macrophage polarization : a review and suggested design principles / Mater Today 18:313~325
Fukazawa T / 2009 / Suppression of the immune response potentiates tadpole tail regeneration during the refractory period / Development 136:2323~2327
Mescher AL / 2005 / Regenerative medicine I / Springer :39~66
Mescher AL / 2013 / Changes in the inflammatory response to injury and its resolution during the loss of regenerative capacity in developing Xenopus limbs / PLoS One 8:e80477
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