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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Background: Tretinoin or all-trans retinoic acid is used in the treatment of acne vulgaris and photo-aging. This work aims to develop tretinoin-loaded nanofibers as a potential anti-acne patch and to investigate its physicochemical characteristics. Method: Nanofibers were produced via electrospinning method and surface topography was evaluated by Field Emission Scanning Electron Microscopy (FESEM). The functional groups of polymer and the drug molecule and the possible interactions were studied by Fourier Transform Infrared Spectroscopy (FTIR). Drug release studies were carried out by total immersion method at 25 °C and 32 °C. Tretinoin stability was evaluated at room temperature and fridge for 45 days. The possibility of synergistic antibacterial activity of tretinoin and erythromycin combination was investigated on Staphylococcus aureus (ATCC® 25923™) and (ATCC® 29213™) by Kirby Bauer disc diffusion method. Results: Uniform fibers without drug crystals were fabricated via electrospinning. Drug-loaded nanofibers show inherent stability under various storage conditions. Electrospun nanofibers showed a prolonged release of tretinoin. The stability of formulations in FT was higher than RT. Disc diffusion tests did not show any synergism in the antibacterial activity of erythromycin when used in combination with tretinoin. Conclusion: It can be anticipated that the easy fabrication, low costs and dosing frequency of the construct reported here provide a platform that can be adapted for on-demand delivery of tretinoin.
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참고문헌 (25)
참고문헌 신청
Leung WWF / 2018 / Microfiber-nanofiber composite filter for high-efficiency and low pressure drop under nano-aerosol loading / Sep Purif Technol 206:26~38
Fathi-Azarbayjani A / 2011 / Development and characterization of skin permeation retardants and enhancers : a comparative study of levothyroxine-loaded PNIPAM, PLA, PLGA and EC microparticles / Biopharm Drug Dispos 32:380~388
Goyal R / 2016 / Nanoparticles and nanofibers for topical drug delivery / J Control Release 240:77~92
Ning W / 2018 / Novel amphiphilic, biodegradable, biocompatible, thermo-responsive ABA triblock copolymers based on PCL and PEG analogues via a combination of ROP and RAFT : synthesis, characterization, and sustained drug release from self-assembled micelles / Polymers 10(2):214
Teraoka R / 2001 / Photochemical and oxidative degradation of the solid-state tretinoin tocoferil / Chem Pharm Bull 49(4):368~372
Fathi-Azarbayjani A / 2011 / Development and characterization of skin permeation retardants and enhancers : a comparative study of levothyroxine-loaded PNIPAM, PLA, PLGA and EC microparticles / Biopharm Drug Dispos 32:380~388
Goyal R / 2016 / Nanoparticles and nanofibers for topical drug delivery / J Control Release 240:77~92
Ning W / 2018 / Novel amphiphilic, biodegradable, biocompatible, thermo-responsive ABA triblock copolymers based on PCL and PEG analogues via a combination of ROP and RAFT : synthesis, characterization, and sustained drug release from self-assembled micelles / Polymers 10(2):214
Teraoka R / 2001 / Photochemical and oxidative degradation of the solid-state tretinoin tocoferil / Chem Pharm Bull 49(4):368~372
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