지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 364 - 375 (12page)
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초록· 키워드
오류제보하기
Background/Aims: Low-level viremia (LLV) after nucleos(t)ide analog treatment was presented as a possible cause of hepatocellular carcinoma (HCC) in patients with chronic hepatitis B (CHB). However, detailed information on patients’ adherence in the real world was lacking. This study aimed to evaluate the effects of LLV on HCC development, mortality, and cirrhotic complications among patients according to their adherence to entecavir (ETV) treatment. Methods: We performed a retrospective observational analysis of data from 894 consecutive adult patients with treatment-naïve CHB undergoing ETV treatment. LLV was defined according to either persistent or intermittent episodes of <2,000 IU/mL detectable hepatitis B virus DNA during the follow-up period. Good adherence to medication was defined as a cumulative adherence ≥90% per study period. Results: Without considering adherence in the entire cohort (n=894), multivariate analysis of the HCC incidence showed that LLV was an independent prognostic factor in addition to other traditional risk factors in the entire cohort (P=0.031). Good adherence group comprised 617 patients (69.0%). No significant difference was found between maintained virologic response and LLV groups in terms of the incidence of liver-related death or transplantation, HCC, and hepatic decompensation in good adherence group, according to multivariate analyses. Conclusions: In patients with treatment-naïve CHB and good adherence to ETV treatment in the real world, LLV during treatment is not a predictive factor for HCC and cirrhotic complications. It may be unnecessary to adjust their antiviral agent for patients with good adherence who experience LLV during ETV treatment.
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등록된 정보가 없습니다.
참고문헌 (35)
참고문헌 신청
Grossi G / 2017 / Hepatitis B virus long-term impact of antiviral therapy nucleot(s)ide analogues (NUCs) / Liver Int 37(Suppl 1):45~51
Zhang QQ / 2011 / Long-term nucleos(t)ide analogues therapy for adults with chronic hepatitis B reduces the risk of long-term complications : a meta-analysis / Virol J 8:72
Peng CY / 2012 / Hepatitis B virus-related decompensated liver cirrhosis : benefits of antiviral therapy / J Hepatol 57:442~450
Liaw YF / 2004 / Lamivudine for patients with chronic hepatitis B and advanced liver disease / N Engl J Med 351:1521~1531
Chang TT / 2010 / Long-term entecavir therapy results in the reversal of fibrosis/cirrhosis and continued histological improvement in patients with chronic hepatitis B / Hepatology 52:886~893
Zhang QQ / 2011 / Long-term nucleos(t)ide analogues therapy for adults with chronic hepatitis B reduces the risk of long-term complications : a meta-analysis / Virol J 8:72
Peng CY / 2012 / Hepatitis B virus-related decompensated liver cirrhosis : benefits of antiviral therapy / J Hepatol 57:442~450
Liaw YF / 2004 / Lamivudine for patients with chronic hepatitis B and advanced liver disease / N Engl J Med 351:1521~1531
Chang TT / 2010 / Long-term entecavir therapy results in the reversal of fibrosis/cirrhosis and continued histological improvement in patients with chronic hepatitis B / Hepatology 52:886~893
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