메뉴 건너뛰기
Library Notice
Institutional Access
If you certify, you can access the articles for free.
Check out your institutions.
ex)Hankuk University, Nuri Motors
Log in Register Help KOR
Subject
Humanities
General Humanities History Philosophy Religious Studies Linguistics and Literature Other Humanities
Social science
General Social Science Business Management Tourism Education Military Science Library and Information Science Law Sociology Journalism and Media Studies Psychological Science Political Science and Diplomacy Geography Public Administration Economics International Trade Anthropology Other Social Science
Natural science
General Natural Science Physics Biology Life Sciences Mathematics/Statistics Astronomy Earth Science Chemistry Other Natural Science
Engineering
General Engineering Architectural Engineering Mechanical Engineering Industrial Engineering Material/Energy Engineering Electrical and Electronic Engineering Marine and Ocean Engineering Chemical Engineering Computer Science Other Engineering
Medical science
General Medical Science Nursing Science Veterinary Pharmacy Traditional Korean Medicine Basic Medicine Clinical Medicine Other Medicine
Agriculture and Fishery
General Agriculture and Fishery Agriculture Fishery Science Food Science Forestry Animal Husbandry Marine Transportation Studies Other Agriculture and Fishery
Art and Kinesiology
General Arts Design Fine Arts Cosmetology Photography Music Fashion Kinesiology Performing Media Arts Other Arts and Kinesiology
Interdisciplinary Studies
Interdisciplinary Research Science and Technology Studies Brain and Cognitive Science Technology Policy Other Interdisciplinary Studies

KOR

Antifungal Activity of Salvia miltiorrhiza Against Candida albicans Is Associated with the Alteration of Membrane Permeability and (1,3)-β-D-Glucan Synthase Activity
Recommendations
Search

논문 기본 정보

Type
Academic journal
Author
Journal
한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제26권 제3호 KCI Accredited Journals SCOPUS
Published
2016.1
Pages
610 - 617 (8page)

Usage

cover
Antifungal Activity of Salvia miltiorrhiza Against Candida albicans Is Associated with the Alteration of Membrane Permeability and (1,3)-β-D-Glucan Synthase Activity
Ask AI
Recommendations
Search

Abstract· Keywords

Report Errors
Candidiasis has posed a serious health risk to immunocompromised patients owing to the increase in resistant yeasts, and Candida albicans is the prominent pathogen of fungal infections. Therefore, there is a critical need for the discovery and characterization of novel antifungals to treat infections caused by C. albicans. In the present study, we report on the antifungal activity of the ethanol extract from Salvia miltiorrhiza against C. albicans and the possible mode of action against C. albicans. The increase in the membrane permeability was evidenced by changes in diphenylhexatriene binding and release of both 260-nm-absorbing intracellular materials and protein. In addition, inhibition of cell wall synthesis was demonstrated by the enhanced minimal inhibitory concentration in the presence of sorbitol and reduced (1,3)-β-D-glucan synthase activity. The above evidence supports the notion that S. miltiorrhiza has antifungal activity against C. albicans by the synergistic activity of targeting the cell membrane and cell wall. These findings indicate that S. miltiorrhiza displays effective activity against C. albicans in vitro and merits further investigation to treat C. albicansassociated infections.
#antifungal activity #Candida albicans #membrane permeability #3)-β-D-glucan synthase #Salvia miltiorrhiza

Contents

No content found

References (33)

Add References
Adams JD / 2006 / Preclinical and clinical examinations of Salvia miltiorrhiza and its tanshinones in ischemic conditions / Chin. Med 1:3 google schola Aricha B / 2004 / Differences in membrane fluidity and fatty acid composition between phenotypic variants of Streptococcus pneumoniae / J. Bacteriol 186:4638~4644 google schola Carrillo-Muñoz AJ / 2006 / Antifungal agents: mode of action in yeast cells / Rev. Esp. Quimioterap 19:130~139 google schola Carson CF / 2002 / Mechanism of action of Melaleuca alternifolia (tea tree) oil on Staphylococcus aureus determined by time-kill, lysis, leakage, and salt tolerance assays and electron microscopy / Antimicrob. Agents Chemother 46:1914~1920 google schola Clinical Laboratory Standards Institute / 2008 / Reference method for broth dilution antifungal susceptibility testing of yeasts / Clinical and Laboratory Standards Institute google schola

Recommendations

It is an article recommended by DBpia according to the article similarity. Check out the related articles!

Related Authors

Recently viewed articles

Capsular Contracture after Calf Augmentation with Silicone Implant Insertion
Seo, Bommie Florence, Choi 외 5명Korean Society Of Plastic And Reconstructive Surgeons2015
 The Korean People in the Japanese Films
Yomota InuhikoThe Center for Japanese Studies 2001.02
 The Implications of North Korea's Development Strategy and Implementation of SDGs-NDGs: Focusing on SDG1 (No Poverty) and SDG2 (Zero Hunger)
Kang Chae Yeon, HWANG IN-YEOPThe Korean Association Of Area Studies2021.09
 The Consciousness and Direction of Classical Chinese Prose Education in the ‘Curriculum of Classical Chinese Education’
Kang, Min - KooThe Korea Association For Education Of Chinese Characters2019

Comments(0)

0

Write first comments.