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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 348 - 355 (8page)
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Cyclophosphamide, a cytotoxic anticancer agent, induces immunosuppression and has several adverse effects. N-acetylcysteine alleviates oxidative stress, liver injury, and intestinal tissue damage. The present study examined whether N-acetylcysteine modulates the adverse effects of cyclophosphamide in pigs. Miniature pigs (n = 15) were used as an experimental model to evaluate the effects of N-acetylcysteine treatment on immune reactions, liver injury, and oxidative stress after cyclophosphamide challenge. Corn-soybean meal based dietary treatments were as follows: control diet with either saline injection, cyclophosphamide injection, or 0.5% N-acetylcysteine and cyclophosphamide injection. N-acetylcysteine increased the number of immune cells and decreased TNF-α production after cyclophosphamide injection and decreased TNF-α, IFN-γ, NF-κB, and IL-8 expression and increased IL- 10 expression in peripheral blood mononuclear cells. Serum levels of alanine transaminase and aspartate aminotransferase decreased, superoxide dismutase activity increased, and malondialdehyde activity decreased following N-acetylcysteine treatment after cyclophosphamide injection. N-acetylcysteine decreases immunosuppression, liver injury, and oxidative stress in cyclophosphamide-challenged miniature pigs. The present study suggests that N-acetylcysteine has therapeutic application in livestock for modulating immune reactions, liver injury, and oxidative stress.
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참고문헌 (30)
참고문헌 신청
El-Abasy M / 2004 / Preventive and therapeutic effects of sugar cane extract on cyclophosphamide-induced immunosuppression in chickens / Int Immunopharmacol 4:983~990
Tayade C / 2006 / L-arginine stimulates immune response in chickens immunized with intermediate plus strain of infectious bursal disease vaccine / Vaccine 24:552~560
Huttunen KM / 2011 / Prodrugs-from serendipity to rational design / Pharmacol Rev 63:750~771
Salem ML / 2009 / Recovery from cyclophosphamide-induced lymphopenia results in expansion of immature dendritic cells which can mediate enhanced prime-boost vaccination antitumor responses in vivo when stimulated with the TLR3 agonist poly(I : C) / J Immunol 182:2030~2040
Montgomery M / 2007 / Mobilization and collection of autologous hematopoietic progenitor/stem cells / Clin Adv Hematol Oncol 5:127~136
Tayade C / 2006 / L-arginine stimulates immune response in chickens immunized with intermediate plus strain of infectious bursal disease vaccine / Vaccine 24:552~560
Huttunen KM / 2011 / Prodrugs-from serendipity to rational design / Pharmacol Rev 63:750~771
Salem ML / 2009 / Recovery from cyclophosphamide-induced lymphopenia results in expansion of immature dendritic cells which can mediate enhanced prime-boost vaccination antitumor responses in vivo when stimulated with the TLR3 agonist poly(I : C) / J Immunol 182:2030~2040
Montgomery M / 2007 / Mobilization and collection of autologous hematopoietic progenitor/stem cells / Clin Adv Hematol Oncol 5:127~136
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