지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Background: Drug-drug interactions (DDIs) in patients using oral anticancer treatment are more common than in those using injectable anticancer agents. In addition, DDIs related to anticancer treatment are known to cause clinically significant outcomes, such as treatment failure and severe toxicity. To prevent these negative outcomes, significant DDIs are monitored and managed using the information provided in drug databases. We aimed to evaluate the consistency of information on clinically significant DDIs for tyrosine kinase inhibitors (TKIs) between representative drug databases. Methods: We selected clinically significant DDIs involving medications that are co-prescribed with TKIs and met the following criteria: the severity level of DDIs was equal or greater than “D” in Lexicomp® or “major” in Micromedex®. We then analyzed the consistency of the severity classification and evidence level between the drug databases. Spearman’s correlation coefficient was used to identify the relationship between DDI information in the drug databases. Results: In total, 627 DDI pairs were identified as clinically significant; information on these was provided by Lexicomp® and Micromedex® for 571 and 438 pairs, respectively, and both drug databases provided information on 382 DDI pairs. There was no correlation between the severity and evidence level of DDIs provided in the two databases; Spearman’s correlation coefficient for Lexicomp® and Micromedex® was -0.009 (p=0.861) and -0.064 (p=0.209), respectively. Conclusion: To judge the significance of DDIs, healthcare providers should consider that the information on DDIs may be different between drug information databases; hence, clinical factors must be considered concurrently.
목차
등록된 정보가 없습니다.
참고문헌 (19)
참고문헌 신청
van Leeuwen RW / 2013 / Prevalence of potential drug-drug interactions in cancer patients treated with oral anticancer drugs / Br J Cancer 108(5):1071~1078
Bowlin SJ / 2013 / Twelvemonth frequency of drug-metabolizing enzyme and transporterbased drug-drug interaction potential in patients receiving oral enzyme-targeted kinase inhibitor antineoplastic agents / Mayo Clin Proc 88(2):139~148
Blower P / 2005 / Drug-drug interactions in oncology : why are they important and can they be minimized / Crit Rev Oncol Hematol 55(2):117~142
Hersh LR / 2017 / Polypharmacy in the Geriatric Oncology Population / Curr Oncol Rep 19(11):73
Wong CM / 2008 / Clinically significant drug-drug interactions between oral anticancer agents and nonanticancer agents : profiling and comparison of two drug compendia / Ann Pharmacother 42(12):1737~1748
Bowlin SJ / 2013 / Twelvemonth frequency of drug-metabolizing enzyme and transporterbased drug-drug interaction potential in patients receiving oral enzyme-targeted kinase inhibitor antineoplastic agents / Mayo Clin Proc 88(2):139~148
Blower P / 2005 / Drug-drug interactions in oncology : why are they important and can they be minimized / Crit Rev Oncol Hematol 55(2):117~142
Hersh LR / 2017 / Polypharmacy in the Geriatric Oncology Population / Curr Oncol Rep 19(11):73
Wong CM / 2008 / Clinically significant drug-drug interactions between oral anticancer agents and nonanticancer agents : profiling and comparison of two drug compendia / Ann Pharmacother 42(12):1737~1748
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