지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
이용수
초록· 키워드
오류제보하기
Objectives: Drug utilization review program in Korea has provided ‘drug combinations to avoid (DCA)’ alerts to physicians and pharmacists to prevent potential adverse drug events or inappropriate drug use. Seven hundred and six DCA pairs have been announced officially by the Ministry of Food and Drug Safety (MFDS) by March, 2015. Some DCA pairs could be grouped based on the drug interaction mechanism and its consequences. This study aimed to investigate the drug-drug interaction (DDI) pairs, which may be potential DCAs, generated by the drug class-drug class interaction method. Methods: Eleven additive/synergistic and one antagonistic drug class-drug class interaction groups were identified. By combining drugs of two interacting drug class groups, numerous DDI pairs were made. The status and severity of DDI pairs were examined using Lexicomp and Micromedex. Also, the DCA listing rate was calculated. Results: Among 258 DDI pairs generated by the drug class-drug class interaction method, only 142 pairs were identified as official DCA pairs by the MFDS. One hundred and four pairs were identified as potential DCA pairs to be listed. QT prolonging agents-QT prolonging agents, triptans-ergot alkaloids, tricyclic antidepressants-monoamine oxidase inhibitors, and dopamine agonists-dopamine antagonists were identified as drug class-drug class interaction groups which have less than 50 % DCA listing rate. Conclusion: To improve the clinicians’ adaptability to DCA alerts, the list of DCA pairs needs to be continuously updated.
목차
등록된 정보가 없습니다.
참고문헌 (14)
참고문헌 신청
/ / Korea Institute of Drug Safety & Risk Management
/ / Ministry of Food and Drug Safety
/ / Yakup Shinmoon
/ 2013 / Drug interactions result from a number of underlying pharmacokinetic and pharmacodynamic mechanisms / Drugs Ther Perspect 29 : 217 ~ 222
Cascorbi I. / 2012 / Drug interactions--principles, examples and clinical consequences / Dtsch Arztebl Int 109 : 546 ~ 555
/ / Ministry of Food and Drug Safety
/ / Yakup Shinmoon
/ 2013 / Drug interactions result from a number of underlying pharmacokinetic and pharmacodynamic mechanisms / Drugs Ther Perspect 29 : 217 ~ 222
Cascorbi I. / 2012 / Drug interactions--principles, examples and clinical consequences / Dtsch Arztebl Int 109 : 546 ~ 555
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