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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국약제학회 Journal of Pharmaceutical Investigation Journal of Pharmaceutical Investigation 제50권 제1호
- 발행연도
- 2020.1
- 수록면
- 81 - 94 (14page)
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초록· 키워드
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Phase separation with solvent exchange induced-in situ forming gel (ISG) is an attractive delivery system for periodontitis treatment. Eudragit ® RS-PO (ERS) in N-methyl pyrrolidone (NMP) was used as polymer matrix for doxycycline hyclate (DH)-loaded solvent-exchanged ISG; however, a high burst drug release was evident. The present study revealed the role of PEG 1500 on physicochemical properties and modification of a burst release for DH-loaded ISG. DH-loaded ISG system comprising PEG 1500 exhibited the Newtonian flow with acceptable injectability with PEG 1500 concentration dependence and high in vitro degradation owing to NMP and PEG 1500 liberation. Solvent exchange between NMP with PBS pH 6.8 conveyed the rapid phase separation of ERS/PEG 1500 as a matrix which the entrapped DH diffused out gradually. Both dialysis membrane and membrane-less methods proved the slower drug release of DH-loaded ERS ISG comprising PEG than PEG 1500-free ISG. SEM revealed the porous matrix topography from polymeric phase separation especially for higher PEG 1500 loading. PEG 1500 incorporation significantly decreased the inhibition diameter against S. aureus, E. coli and S. mutans (P < 0.05) indicating the retardation of drug release owing to the high viscosity of the PEG 1500. PEG 1500-incorporated DH-loaded ERS ISG exhibited the potential use for periodontitis treatment.
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참고문헌 (52)
참고문헌 신청
Abashzadeh R / 2011 / Formulation and evaluation of an in situ gel forming system for controlled delivery of triptorelin acetate / Eur J Pharm Sci 44:514~521
Ahmed TA / 2012 / Development of biodegradable in situ implant and microparticle injectable formulations for sustained delivery of haloperidol / J Pharm Sci 10:3753~3762
Arendt-Nielsen L / 2006 / Pain following controlled cutaneous insertion of needles with different diameters / Somatosens Mot Res 23:37~43
Bodmeier R / 1997 / Plasticizer uptake by aqueous colloidal polymer dispersions used for the coating of solid dosage forms / Int J Pharm 52:17~26
Brodbeck KJ / 1999 / Phase inversion dynamics of PLGA solutions related to drug delivery. Part II. The role of solution thermodynamics and bathside mass transfer / J Control Release 62:333~344
Ahmed TA / 2012 / Development of biodegradable in situ implant and microparticle injectable formulations for sustained delivery of haloperidol / J Pharm Sci 10:3753~3762
Arendt-Nielsen L / 2006 / Pain following controlled cutaneous insertion of needles with different diameters / Somatosens Mot Res 23:37~43
Bodmeier R / 1997 / Plasticizer uptake by aqueous colloidal polymer dispersions used for the coating of solid dosage forms / Int J Pharm 52:17~26
Brodbeck KJ / 1999 / Phase inversion dynamics of PLGA solutions related to drug delivery. Part II. The role of solution thermodynamics and bathside mass transfer / J Control Release 62:333~344
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