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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국약제학회 Journal of Pharmaceutical Investigation Journal of Pharmaceutical Investigation 제49권 제1호
- 발행연도
- 2019.1
- 수록면
- 115 - 125 (11page)
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초록· 키워드
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RIPL peptide-conjugated liposomes (PEG-RIPL-Ls) were sterically stabilized with polyethylene glycol (PEG) to prevent recognition by the mononuclear phagocytic system (MPS) and prolong their systemic circulation in vivo. PEG-modified maleimide-derivatized liposomes were prepared by a thin-film hydration method and RIPL peptide was conjugated via a thiol-maleimide reaction. To optimize the system, different chain lengths of PEG were used to prepare PEG-RIPL-L. PEG-RIPL-Ls were positively charged nanodispersions and docetaxel (DTX) was successfully encapsulated by pre-loading with an encapsulation efficiency and drug loading capacity of 31–35% and 15–20 μg/mg, respectively. DTX release showed a biphasic pattern, with rapid release in the initial period of 6 h, followed by sustained release for up to 72 h. Additionally, 5 mol% PEG3000-grafted RIPL-L (PEG3K-RIPL-L) showed enhanced anti-adsorption compared to 5 mol% PEG2000- grafted RIPL-L (PEG2K-RIPL-L). Confocal microscopy and flow cytometry using a fluorescence probe (FITC-dextran) demonstrated the greatest stealth effect of PEG3K-RIPL-L. Further analysis of cellular uptake showed that PEG3K-RIPL-L maintained target-selective intracellular delivery capacity. Cytotoxicity analysis demonstrated that PEG3K-RIPL-L had a 1.8-fold lower IC50 value than DTX-Sol. Steric stabilization of RIPL-L was successfully achieved by surface modification with PEG3K, and thus PEG3K-RIPL-L shows potential as a nanocarrier for targeted drug delivery in blood circulation.
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참고문헌 (27)
참고문헌 신청
Allen TM / 1997 / Liposomes : opportunities in drug delivery / Drugs 54:8~14
Blunk T / 1993 / Colloidal carriers for intravenous drug targeting : plasma protein adsorption patterns on surface-modified latex particles evaluated by two-dimensional polyacrylamide gel electrophoresis / Electrophoresis 14:1382~1387
Bozzuto G / 2015 / Liposomes as nanomedical devices / Int J Nanomed 10:975~999
Essa S / 2011 / Characterization of rhodamine loaded PEG-g-PLA nanoparticles(NPs) : effect of poly(ethylene glycol)grafting density / Int J Pharm 411:178~187
Fanciullino R / 2009 / Liposome-encapsulated anticancer drugs: still waiting for the magic bullet? / Curr Med Chem 16:4361~4373
Blunk T / 1993 / Colloidal carriers for intravenous drug targeting : plasma protein adsorption patterns on surface-modified latex particles evaluated by two-dimensional polyacrylamide gel electrophoresis / Electrophoresis 14:1382~1387
Bozzuto G / 2015 / Liposomes as nanomedical devices / Int J Nanomed 10:975~999
Essa S / 2011 / Characterization of rhodamine loaded PEG-g-PLA nanoparticles(NPs) : effect of poly(ethylene glycol)grafting density / Int J Pharm 411:178~187
Fanciullino R / 2009 / Liposome-encapsulated anticancer drugs: still waiting for the magic bullet? / Curr Med Chem 16:4361~4373
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