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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제18권 제2호
- 발행연도
- 2020.1
- 수록면
- 303 - 310 (8page)
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초록· 키워드
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Objective: Long-acting injectable (LAI) antipsychotics, such as paliperidone palmitate (PP), are known to improve treatment adherence in patients with schizophrenia, which can lead to reductions in relapse and hospitalization rates. However, relatively few studies have demonstrated the economic impact of LAIs, especially in Asian populations. Methods: We conducted a claim-based mirror-image study to explore changes in healthcare utilization and associated costs, among 1,272 South Korean patients with schizophrenia (ICD-10-CM code F20), between the 1-year periods before and after the initiation of PP treatment. Results: Patients accessed outpatient services more frequently after versus before starting PP treatment, with the number of prescription days increasing by 133.45 (p ＜ 0.0001) and the associated costs increasing by USD 1,497.15 (p ＜ 0.0001). The number of admission days was reduced by 11.33 after starting PP treatment (p ＜ 0.0001) and the associated costs were reduced by USD 1,220.75 (p ＜ 0.0001). However, admission cost savings were different according to patients’ oral drug compliance. The daily dosages for benztropine, procyclidine, and propranolol decreased, showing that there were fewer side-effects after PP-treatment (p ＜ 0.0001). Conclusion: Although the high acquisition cost of PP has been regarded as an obstacle to its clinical use, our results imply that the high prescription costs for PP may be counterbalanced by the reduced admission costs associated with its use. Economic outcomes for patients treated with LAIs should be investigated further to help healthcare decision-makers and providers to determine the value of LAIs relative to other treatment medications.
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참고문헌 (26)
참고문헌 신청
World Health Organization / World Health Organization health topics: schizophrenia
Chien WT / 2013 / Current approaches to treatments for schizophrenia spectrum disorders, part I : an overview and medical treatments / Neuropsychiatr Dis Treat 9:1311~1332
Zhang F / 2015 / Efficacy, safety, and impact on hospitalizations of paliperidone palmitate in recent-onset schizophrenia / Neuropsychiatr Dis Treat 11:657~668
Morrato EH / 2015 / Comparative effectiveness of injectable paliperidone palmitate versus oral atypical antipsychotics : early postmarketing evidence / J Comp Eff Res 4:89~99
Einarson TR / 2012 / Pharmacoeconomic analysis of paliperidone palmitate for treating schizophrenia in Greece / Ann Gen Psychiatry 11:18
Chien WT / 2013 / Current approaches to treatments for schizophrenia spectrum disorders, part I : an overview and medical treatments / Neuropsychiatr Dis Treat 9:1311~1332
Zhang F / 2015 / Efficacy, safety, and impact on hospitalizations of paliperidone palmitate in recent-onset schizophrenia / Neuropsychiatr Dis Treat 11:657~668
Morrato EH / 2015 / Comparative effectiveness of injectable paliperidone palmitate versus oral atypical antipsychotics : early postmarketing evidence / J Comp Eff Res 4:89~99
Einarson TR / 2012 / Pharmacoeconomic analysis of paliperidone palmitate for treating schizophrenia in Greece / Ann Gen Psychiatry 11:18
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