지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Controlled drug release is important for effective treatment of cancer. Poly(DL-lactide-co-glycolide) acid (PLGA) is a Food and Drug Administration (FDA) approved polymer and have been extensively studied as drug delivery carriers with biodegradable and biocompatible properties. However, PLGA drug delivery carriers are limited due to the initial burst release of drug. Certain drugs require an early rapid release, but in many cases the initial rapid release can be inefficient, reducing therapeutic effects and also increasing side effects. Therefore, sustained release is important for effective treatment. Poly Lactic Acid stereo complex (PLA SC) is resistant to hydrolysis and has high stability in aqueous solutions. Therefore, in this work, PLGA based discoidal polymeric particles are modified by Poly Lactic Acid stereocomplex (PLAsc DPPs). PLAsc DPPs are 3 μm in diameter, also showing a relatively sustained release profile. Fluorescein 5(6)-isothiocyanate (FITC) released from PLAsc DPPs was continuously observed until 38 days, which showed the initial release of FITC from PLAsc DPPs was about 3.9-fold reduced as compared to PLGA based DPPs at 1 hour.
목차
등록된 정보가 없습니다.
참고문헌 (27)
참고문헌 신청
TGJr CBR / 2005 / Timeline : chemotherapy and the war on cancer / Nat Rev Cancer 5:6572
Singh RP / 2017 / Chitosan-folate decorated carbon nanotubes for site specific lung cancer delivery / Materials Science and Engineering : C 77:446~458
Mignani S / 2014 / Advances in combination therapies based on nanoparticles for efficacious cancer treatment : an analytical report / Biomacromolecules 16:1~27
Pérez-Herrero E / 2015 / Advanced targeted therapies in cancer : drug nanocarriers, the future of chemotherapy / European journal of pharmaceutics and biopharmaceutics 93:52~79
Senapati S / 2018 / Controlled drug delivery vehicles for cancer treatment and their performance / Signal transduction and targeted therapy 3:7
Singh RP / 2017 / Chitosan-folate decorated carbon nanotubes for site specific lung cancer delivery / Materials Science and Engineering : C 77:446~458
Mignani S / 2014 / Advances in combination therapies based on nanoparticles for efficacious cancer treatment : an analytical report / Biomacromolecules 16:1~27
Pérez-Herrero E / 2015 / Advanced targeted therapies in cancer : drug nanocarriers, the future of chemotherapy / European journal of pharmaceutics and biopharmaceutics 93:52~79
Senapati S / 2018 / Controlled drug delivery vehicles for cancer treatment and their performance / Signal transduction and targeted therapy 3:7
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