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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제24권 제3호
- 발행연도
- 2020.1
- 수록면
- 259 - 266 (8page)
이용수
초록· 키워드
오류제보하기
Cardiovascular diseases are the primary reason of mortality, among which myocardial infarction (MI) is the most dominant and prevalent. This study was considered to examine D-Limonene protective action against isoproterenol (ISO) induced MI. Wister male rats were dispersed into four groups. Normal and D-Limonene control group in which rats administered saline or D-Limonene. ISO control animals were administered saline for 21 days then challenged with ISO (85 mg/kg, subcutaneously) on 20th and 21st day for MI induction. D-Limonene pretreated group in which animals were pretreated with D-Limonene 50 mg/kg orally for 21 days then administered ISO on 20th and 21st day. MI prompted variations were assessed by myocardial infarction area determination, blood pressure (BP) alterations, cardiac injury biomarkers and inflammatory mediators measurements. For more depth investigation, both the apoptotic status was evaluated via measuring mRNA expression of Bcl-2 and Bax as well as mitogen-activated protein kinase-extracellular signal-regulated kinase (MAPK-ERK) signal transduction were investigated via Western blotting. MI group revealed significant infarcted area, blood pressure alterations, myocardial injury enzymes intensification together with inflammatory cytokines amplification. MI was associated with activation of MAPK-ERK signal pathway and apoptotic status within the myocardium. On the other hand, pretreated with D-Limonene demonstrated deterred infracted area, reduced myocardial enzymes, improved BP indices, lessened inflammatory levels. Furthermore, D-Limonene pretreatment caused a decline in MAPK proteins pathway and Bax relative mRNA expression, while intensifying Bcl-2 mRNA expression promoting that D-Limonene may constrain MI induced myocardial apoptosis. D-Limonene mitigated MI injury through MAPK/NF-κB pathway inhibition and anti-apoptotic effect.
목차
등록된 정보가 없습니다.
참고문헌 (33)
참고문헌 신청
Sun J / 2007 / D-Limonene : safety and clinical applications / Altern Med Rev 12:259~264
de Souza MC / 2019 / Gastroprotective effect of limonene in rats : influence on oxidative stress, inflammation and gene expression / Phytomedicine 53:37~42
Kummer R / 2013 / Evaluation of anti-inflammatory activity of citrus latifolia tanaka essential oil and limonene in experimental mouse models / Evid Based Complement Alternat Med 2013:859083
Hirota R / 2010 / Anti-inflammatory effects of limonene from yuzu(Citrus junos Tanaka)essential oil on eosinophils / J Food Sci 75:H87~92
Rufino AT / 2015 / Evaluation of the anti-inflammatory, anti-catabolic and pro-anabolic effects of E-caryophyllene, myrcene and limonene in a cell model of osteoarthritis / Eur J Pharmacol 750:141~150
de Souza MC / 2019 / Gastroprotective effect of limonene in rats : influence on oxidative stress, inflammation and gene expression / Phytomedicine 53:37~42
Kummer R / 2013 / Evaluation of anti-inflammatory activity of citrus latifolia tanaka essential oil and limonene in experimental mouse models / Evid Based Complement Alternat Med 2013:859083
Hirota R / 2010 / Anti-inflammatory effects of limonene from yuzu(Citrus junos Tanaka)essential oil on eosinophils / J Food Sci 75:H87~92
Rufino AT / 2015 / Evaluation of the anti-inflammatory, anti-catabolic and pro-anabolic effects of E-caryophyllene, myrcene and limonene in a cell model of osteoarthritis / Eur J Pharmacol 750:141~150
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