지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제23권 제3호
- 발행연도
- 2019.1
- 수록면
- 203 - 217 (15page)
이용수
초록· 키워드
오류제보하기
The present study was designed to examine the effect of heme oxygenase- 1 (HO-1) induction by cobalt protoporphyrin (CoPP) on the cardiac functions and morphology, electrocardiogram (ECG) changes, myocardial antioxidants (superoxide dismutase [SOD] and glutathione [GSH]), and expression of heat shock protein (Hsp) 70 and connexin 43 (Cx-43) in myocardial muscles in isoproterenol (ISO) induced myocardial infarction (MI). Thirty two adult male Sprague Dawely rats were divided into 4 groups (each 8 rats): normal control (NC) group, ISO group: received ISO at dose of 150 mg/kg body weight intraperitoneally (i.p.) for 2 successive days; ISO + Trizma group: received (ISO) and Trizma (solvent of CoPP) at dose of 5 mg/kg i.p. injection 2 days before injection of ISO, with ISO at day 0 and at day 2 after ISO injections; and ISO + CoPP group: received ISO and CoPP at a dose of 5 mg/kg dissolved in Trizma i.p. injection as Trizma. We found that, administration of ISO caused significant increase in heart rate, corrected QT interval, ST segment, cardiac enzymes (lactate dehydrogenase, creatine kinase-muscle/brain), cardiac HO-1, Hsp70 with significant attenuation in myocardial GSH, SOD, and Cx-43. On the other hand, administration of CoPP caused significant improvement in ECG parameters, cardiac enzymes, cardiac morphology; antioxidants induced by ISO with significant increase in HO-1, Cx-43, and Hsp70 expression in myocardium. In conclusions, we concluded that induction of HO-1 by CoPP ameliorates ISO-induced myocardial injury, which might be due to up-regulation of Hsp70 and gap junction protein (Cx-43)
목차
등록된 정보가 없습니다.
참고문헌 (60)
참고문헌 신청
Yusuf S / 2003 / Tackling the growing global burden of atherosclerotic cardiovascular diseases / Eur J Cardiovasc Prev Rehabil 10:236~239
Hashmi S / 2015 / Acute myocardial infarction and myocardial ischemia-reperfusion injury : a comparison / Int J Clin Exp Pathol 8:8786~8796
Sathish V / 2003 / Synergistic effect of Nicorandil and Amlodipine on tissue defense system during experimental myocardial infarction in rats / Mol Cell Biochem 243:133~138
Mahammad Rahmathulla SB / 2013 / Origination and development of isoproterenol-induced myocardial infarction in male wistar rats / Int Res J Pharm 4:26~35
Maines MD / 1988 / Heme oxygenase : function, multiplicity, regulatory mechanisms, and clinical applications / FASEB J 2:2557~2568
Hashmi S / 2015 / Acute myocardial infarction and myocardial ischemia-reperfusion injury : a comparison / Int J Clin Exp Pathol 8:8786~8796
Sathish V / 2003 / Synergistic effect of Nicorandil and Amlodipine on tissue defense system during experimental myocardial infarction in rats / Mol Cell Biochem 243:133~138
Mahammad Rahmathulla SB / 2013 / Origination and development of isoproterenol-induced myocardial infarction in male wistar rats / Int Res J Pharm 4:26~35
Maines MD / 1988 / Heme oxygenase : function, multiplicity, regulatory mechanisms, and clinical applications / FASEB J 2:2557~2568
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
제약산업과 ISO 37001
KPBMA Brief
2018 .01
-
ISO 26000 적용을 위한 의료기관의 사회적 책임활동에 대한 고찰
보건의료산업학회지
2018 .01
-
Modulation of Melanogenesis by Heme Oxygenase-1 via p53 in Normal Human Melanocytes
전남의대학술지
2016 .01
-
International Organization for Standardization (ISO) 15189
Annals of Laboratory Medicine
2017 .01
-
Effect of Low-Intensity Cardiac Rehabilitation on Cardiac Function and Degree of Fibrosis in a White Rat Acute Myocardial Infarction Model
Journal of international academy of physical therapy research
2016 .01
-
The influence of Geometric and Elastic parameters on FEA Stress estimation of ISO 4049 Flexural test specimen
대한치과재료학회 학술대회
2022 .11
-
한국 치과재료학 100년과 ISO/TC 106
대한치과재료학회 학술대회
2015 .11
-
D-Limonene mitigate myocardial injury in rats through MAPK/ ERK/NF-κB pathway inhibition
The Korean Journal of Physiology & Pharmacology
2020 .01
-
Effects of Low intensity Cardiac Rehabilitation Exercise on Weight and Histological Changes of Rat Models with Acute Myocardial Infarction
Journal of international academy of physical therapy research
2016 .01
-
Myocardial Efficiency: A Reliable Load-independent Parameter of Cardiac Performance?
Journal of Cardiovascular Imaging
2020 .01
-
The association of Hsp90 expression induced by aspirin with anti-stress damage in chicken myocardial cells
Journal of Veterinary Science
2016 .03
-
Anti-proliferation Effects of Isorhamnetin on Lung Cancer Cells in Vitro and in Vivo
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Trends in Distributions of Hearing Threshold Levels by Ages: A Comparison of the ISO 7029 and Newly Available Country-Specific Data
Journal of Audiology & Otology
2024 .01
-
대기 오염 물질과 급성심근경색의 상관 관계 연구
대한응급의학회지
2020 .01
-
Discussion of the application of the new standard for irritation test (ISO 10993-23) in GLP facility
한국실험동물학회 학술발표대회 논문집
2021 .07
-
Cardiac arrest due to an unexpected acute myocardial infarction during head and neck surgery: A case report
Journal of dental anesthesia and pain medicine
2018 .01
-
Role of Cardiac Computed Tomography in the Diagnosis of Left Ventricular Myocardial Diseases
Journal of Cardiovascular Imaging
2019 .01
-
검안 시 급성심근경색 진단을 위한 심근효소 검사의 유용성
대한법의학회지
2019 .01
-
급성심근경색 사후 진단을 위한 심장 표지자 검사의 유용성
대한법의학회지
2021 .01
-
Compliance with Health Behavior in Patients Diagnosed with Myocardial Infarction
성인간호학회 학술대회
2019 .05
이 논문의 저자 정보
최근 본 자료
댓글(0)
0