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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제23권 제6호
- 발행연도
- 2019.1
- 수록면
- 493 - 499 (7page)
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초록· 키워드
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Macrophage-associated inflammation is crucial for the pathogenesis of diverse diseases including metabolic disorders. Rhodanthpyrone (Rho) is an active component of Gentiana rhodantha, which has been used in traditional Chinese medicine to treat inflammation. Although synthesis procedures of RhoA and RhoB were reported, the biological effects of the specific compounds have never been explored. In this study, the anti-inflammatory activity and mechanisms of action of RhoA and RhoB were studied in lipopolysaccharide (LPS)-stimulated macrophages. Pretreatment with RhoA and RhoB decreased inducible nitric oxide synthase and cyclooxygenase- 2 expressions in RAW 264.7 cells and in thioglycollate-elicited mouse peritoneal macrophages. In addition, it downregulated transcript levels of several inflammatory genes in LPS-stimulated RAW 264.7 cells, including inflammatory cytokines/ chemokines (Tnfa, Il6, and Ccl2) and inflammatory mediators (Nos2 and Ptgs2). Macrophage chemotaxis was also inhibited by treatment with the compounds. Mechanistic studies revealed that RhoA and RhoB suppressed the nuclear factor (NF)-κB pathway, but not the canonical mitogen activated protein kinase pathway, in LPS-stimulated condition. Moreover, the inhibitory effect of RhoA and RhoB on inflammatory gene expressions was attenuated by treatment with an NF-κB inhibitor. Our findings suggest that RhoA and RhoB play an anti-inflammatory role at least in part by suppressing the NF-κB pathway during macrophage-mediated inflammation.
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참고문헌 (21)
참고문헌 신청
Okin D / 2012 / Evolution of inflammatory diseases / Curr Biol 22:R733~R740
Wynn TA / 2013 / Macrophage biology in development, homeostasis and disease / Nature 496:445~455
Schultze JL / 2015 / Macrophage activation in human diseases / Semin Immunol 27:249~256
de Jesus AA / 2015 / Molecular mechanisms in genetically defined autoinflammatory diseases : disorders of amplified danger signaling / Annu Rev Immunol 33:823~874
Vallabhapurapu S / 2009 / Regulation and function of NF-kappaB transcription factors in the immune system / Annu Rev Immunol 27:693~733
Wynn TA / 2013 / Macrophage biology in development, homeostasis and disease / Nature 496:445~455
Schultze JL / 2015 / Macrophage activation in human diseases / Semin Immunol 27:249~256
de Jesus AA / 2015 / Molecular mechanisms in genetically defined autoinflammatory diseases : disorders of amplified danger signaling / Annu Rev Immunol 33:823~874
Vallabhapurapu S / 2009 / Regulation and function of NF-kappaB transcription factors in the immune system / Annu Rev Immunol 27:693~733
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