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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 506 - 516 (11page)
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초록· 키워드
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Objective Post-traumatic stress disorder (PTSD) and chronic pain often co-occur. Studies have shown an interaction between pain and PTSD. In this narrative review, we aim to support conducting comprehensive studies by describing PTSD, pain and determining whether opioidergic system, its agonist and antagonist manipulation could positively or negatively affect PTSD symptoms and concurrent pain.Methods Term searches was done in Google Scholar, Scopus, ScienceDirect, Web of Science and PubMed databases as well as hand searching in key resource journals from 1979–2019.Results There are a lot of contradictions and disputes when endogenous opioidergic system and opioidergic antagonist system are studied in PTSD patients. Exogenous morphine administration in PTSD patients can decrease the symptoms of PTSD but it doesn’t have a pain reduction effect to an acceptable level. Beta-endorphin as an endogenous opioid is effective in pain reduction in the moment of events but after minutes to hours, the endorphins withdrawal syndrome leads to exaggerated intrusive thoughts and flashbacks of PTSD, which exacerbate the pain. It has also been shown that naloxone, as an opioidergic antagonist, can reduce or increase the PTSD symptoms and its associated pain.Conclusion Data suggest different roles of opioidergic system and their antagonist in pain control and mood in PTSD. However, further investigations need to be done in order to reveal the role of endogenous opioidergic system and opioidergic antagonist system as a mediator in PTSD patients suffering from acute or chronic pain.
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참고문헌 (126)
참고문헌 신청
Wang CH / 2005 / Post-traumatic stress disorder, depression, anxiety and quality of life in patients with traffic-related injuries / J Adv Nurs 52:22~30
Shalev A / 2017 / Post-traumatic stress disorder / N Engl J Med 376:2459~2469
Adhikari Baral I / 2019 / Post traumatic stress disorder and coping strategies among adult survivors of earthquake, Nepal / BMC Psychiatry 19:118
Spitzer RL / 1980 / Diagnostic and statistical manual of mental disorders / Paper presented at: American Psychiatric Association
Asmundson GJ / 2002 / PTSD and the experience of pain : research and clinical implications of shared vulnerability and mutual maintenance models / Can J Psychiatry 47:930~937
Shalev A / 2017 / Post-traumatic stress disorder / N Engl J Med 376:2459~2469
Adhikari Baral I / 2019 / Post traumatic stress disorder and coping strategies among adult survivors of earthquake, Nepal / BMC Psychiatry 19:118
Spitzer RL / 1980 / Diagnostic and statistical manual of mental disorders / Paper presented at: American Psychiatric Association
Asmundson GJ / 2002 / PTSD and the experience of pain : research and clinical implications of shared vulnerability and mutual maintenance models / Can J Psychiatry 47:930~937
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