지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 130 - 139 (10page)
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초록· 키워드
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Objective Immunomodulation is a therapeutic technique that modulates the balance of cytokines in the body. In this regard, our experiment was conducted to investigate the potential effect of S. coronopifolius crude extract in combination with low dose of Bacillus Calmette- Guerin (BCG) on depression-like behaviors in female Wistar rats. Methods Sciatic nerve injury was employed to induce depression and intradermal injection of 0.02 mL of BCG per rat was administered to lead an activation of innate immune system. Daily intra-peritoneal injections of 25 mg algae extract kg-1 body weight were performed for 14 continuous days. Forced Swimming (FS) and Open Field (OF) tests were conducted to assess despairing and spontaneous behaviors. At the end of the experiment, brain was removed to determine the activities of catalase (CAT) and glutathione-S-transferase (GST), whereas spleen and adrenals were used for the histopathological study. Results The combined treatment exhibited antidepressant-like activity in FST by reducing immobility time, without inducing any significant change in ambulatory behavior in OFT. The histological analyses of spleen and adrenal structure showed a conserved architecture. Conclusion The results suggested that algae extract produce an antidepressant-like effect in combination with low dose of BCG, which is possibly trigged by its anti-oxidant and anti-inflammatory properties.
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등록된 정보가 없습니다.
참고문헌 (69)
참고문헌 신청
Díaz AF / 2019 / Analgesic and antidepressant effects of Oltipraz on neuropathic pain in mice by modulating microglial activation / J Clin Med 8:pii: E890
Ferreira-Chamorro P / 2018 / Sulforaphane inhibited the nociceptive responses, anxietyand depressive-like behaviors associated with neuropathic pain and improved the anti-allodynic effects of morphine in mice / Front Pharmacol 9:1332
Akkol EK / 2019 / Assessment of antidepressant effect of the aerial parts of micromeria myrtifolia Boiss. & Hohen on mice / Molecules 24:pii: E1869
Rutledge RB / 2017 / Association of neural and emotional impacts of reward prediction errors with major depression / JAMA Psychiatry 74:790~797
Wang J / 2018 / An extract of Artemisia dracunculus L. promotes psychological resilience in a mouse model of depression / Oxid Med Cell Longev 2018:7418681
Ferreira-Chamorro P / 2018 / Sulforaphane inhibited the nociceptive responses, anxietyand depressive-like behaviors associated with neuropathic pain and improved the anti-allodynic effects of morphine in mice / Front Pharmacol 9:1332
Akkol EK / 2019 / Assessment of antidepressant effect of the aerial parts of micromeria myrtifolia Boiss. & Hohen on mice / Molecules 24:pii: E1869
Rutledge RB / 2017 / Association of neural and emotional impacts of reward prediction errors with major depression / JAMA Psychiatry 74:790~797
Wang J / 2018 / An extract of Artemisia dracunculus L. promotes psychological resilience in a mouse model of depression / Oxid Med Cell Longev 2018:7418681
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