Association between Retinal Vascular Geometric Changes and Cognitive Impairment: A Systematic Review and Meta-Analysis

Huiqun Wu; Chendong Wang; Cong Chen; Xiaotao Xu; Yi Zhu; Aimin Sang; Kui Jiang; Jiancheng Dong

Association between Retinal Vascular Geometric Changes and Cognitive Impairment: A Systematic Review and Meta-Analysis

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Type: Academic journal

Author: Huiqun Wu Chendong Wang Cong Chen Xiaotao Xu Yi Zhu Aimin Sang Kui Jiang Jiancheng Dong

Journal: 대한신경과학회 Journal of Clinical Neurology Journal of Clinical Neurology 제16권 제1호 KCI Accredited Journals

Published: 2020.1

Pages: 19 - 28 (10page)

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Association between Retinal Vascular Geometric Changes and Cognitive Impairment: A Systematic Review and Meta-Analysis

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Background and Purpose Previous studies have explored the association between retinal vascular changes and cognitive impairment. The retinal vasculature shares some characteristics with the cerebral vasculature, and quantitative changes in it could indicate cognitive impairment. Hence, a comprehensive meta-analysis was performed to clarify the potential relationship between retinal vascular geometric changes and cognitive impairment. Methods Relevant databases were scrupulously and systematically searched for retinal vascular geometric changes including caliber, tortuosity, and fractal dimension (FD), and for cognitive impairment. The Newcastle-Ottawa Scale was used to evaluate the methodological quality of included studies. RevMan was used to perform the meta-analysis and detect publication bias. Sensitivity analyses were also performed. Results Five studies that involved 2,343 subjects were finally included in the meta-analysis. The results showed that there was no significant association between central retinal artery equivalents (Z=1.17) or central retinal venular equivalents (Z=1.74) and cognitive impairment (both p>0.05). Similarly, no significant difference was detected in retinal arteriolar tortuosity (Z=0.91) and venular tortuosity (Z=1.31) (both p>0.05). However, the retinal arteriolar FD (mean difference: -0.03, 95% CI: -0.05, -0.01) and venular FD (mean difference: -0.03, 95% CI: -0.05, -0.02) were associated with cognitive impairment. Conclusions A smaller retinal microvascular FD might be associated with cognitive impairment. Further large-sample and well-controlled original studies are required to confirm the present findings.

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Reitz C / 2011 / Epidemiology of Alzheimer disease / Nat Rev Neurol 7:137~152

Petersen RC / 2010 / Prevalence of mild cognitive impairment is higher in men. The Mayo Clinic Study of Aging / Neurology 75:889~897

Jiang YS / 2015 / Retinal microvascular pathology and vascular risk factors in cognitive impairment: a cross-sectional study

James BD / 2014 / Contribution of Alzheimer disease to mortality in the United States / Neurology 82:1045~1050

Lesage SR / 2009 / Retinal microvascular abnormalities and cognitive decline : the ARIC 14-year follow-up study / Neurology 73:862~868

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