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자료유형
학술저널
저자정보
문재훈 (분당서울대학교병원)
저널정보
대한내분비학회 Endocrinology and Metabolism Endocrinology and Metabolism Vol.31 No.2
발행연도
2016.1
수록면
185 - 192 (8page)

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Cognitive impairment, including Alzheimer’s disease and other kinds of dementia, is a major health problem in older adults worldwide. Although numerous investigators have attempted to develop effective treatment modalities or drugs, there is no reasonablyefficacious strategy for preventing or recovering from cognitive impairment. Therefore, modifiable risk factors for cognitive impairmenthave received attention, and the growing literature of metabolic risk factors for cognitive impairment has expanded fromepidemiology to molecular pathogenesis and therapeutic management. This review focuses on the epidemiological evidence for theassociation between cognitive impairment and several endocrine risk factors, including insulin resistance, dyslipidemia, thyroiddysfunction, vitamin D deficiency, and subclinical atherosclerosis. Researches suggesting possible mechanisms for this associationare reviewed. The research investigating modifiable endocrine risk factors for cognitive impairment provides clues for understandingthe pathogenesis of cognitive impairment and developing novel treatment modalities. However, so far, interventional studiesinvestigating the beneficial effect of the “modification” of these “modifiable risk factors” on cognitive impairment have reportedvariable results. Therefore, well-designed, randomized prospective interventional studies are needed.

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