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Background/Aims: Endoscopic ultrasonography (EUS) is the most effcient imaging modality for gastric subepithelial tumors (SETs). However, abdominopelvic computed tomography (APCT) has other advantages in evaluating the characteristics, local extension,or invasion of SETs to adjacent organs. This study aimed to compare the diagnostic ability of EUS and APCT based on surgicalhistopathology results. Methods: We retrospectively reviewed data from 53 patients who underwent both EUS and APCT before laparoscopic wedge resectionfor gastric SETs from January 2010 to December 2017 at a single institution. On the basis of histopathology results, we assessed thediagnostic ability of the 2 tests. Results: The overall accuracy of EUS and APCT was 64.2% and 50.9%, respectively. In particular, the accuracy of EUS vs. APCT for thediagnosis of gastrointestinal stromal tumors (GISTs), leiomyomas, and ectopic pancreas was 83.9% vs. 74.2%, 37.5% vs. 0.0%, and 57.1%vs. 14.3%, respectively. Most of the incorrect diagnoses with EUS involved hypoechoic lesions originating in the fourth echolayer, withthe most common misdiagnosed lesions being GISTs mistaken for leiomyomas and vice versa. Conclusions: APCT showed a lower overall accuracy than EUS; however, APCT remains a useful modality for malignant/potentiallymalignant gastric SETs.

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