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ObjectiveThe aim of this systematic review and meta-analysis study was to determine the pooled estimate of the effect ofantenatal magnesium sulfate (MgSO4) on intraventricular hemorrhage (IVH) in premature infants. MethodsTwo review authors independently searched all randomized clinical trials from international databases, includingMedline (PubMed), Web of Sciences, Scopus, Cochrane Central Register of Controlled Trials (CENTRAL), and ResearchRegisters of ongoing trials (ClinicalTrials.gov), from January 1989 to August 2017. Two independent review authorswere responsible for data collection. After extracting the necessary information from the evaluated articles, meta-analysis of the data was performed using Stata version 14. Also, sources of heterogeneity among studies weredetermined by Meta regression. ResultsIn this study, among 126 articles that were extracted from primary studies, 7 papers that evaluated the effect ofMgSO4 on IVH were eligible for inclusion in the meta-analysis. The results of the meta-analysis showed that pooledrelative risk (95% confidence interval [CI]) was 0.80 (95% CI, 0.63 to 1.03) for the effect of MgSO4 on IVH. ConclusionResults of this study showed that although MgSO4 had a protective effect on IVH in premature infants, this effect wasnot statistically significant. Further studies are needed to determine the best dosage, timing, and gestational age toachieve the optimum effect of MgSO4 on IVH.

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