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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 1 - 7 (7page)
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Oral lichen planus (OLP) is a chronic inflammatory disease observed in approximately 0.5–2.2% of the population, and it is recognized as a premalignant lesion that can progress into oral squamous cell carcinoma (OSCC). The rate of malignant transformation is approximately 1.09–2.3%, and the risk factors for malignant transformation are age, female, erosive type, and tongue site location. Malignant transformation of OLP is likely related to the low frequency of apoptotic phenomena. Therefore, apoptosis-related genetic factors, like p53, BCL-2, and BAX are reviewed. Increased p53 expression and altered expression of BCL-2 and BAX were observed in OLP patients, and the malignant transformation rate in these patients was relatively higher. The involvement of microRNA (miRNA) in the malignant transformation of OLP is also reviewed. Because autophagy is involved in cell survival and death through the regulation of various cellular processes, autophagy-related genetic factors may function as factors for malignant transformation. In OLP, decreased levels of ATG9B mRNA and a higher expression of IGF1 were observed, suggesting a reduction in cell death and autophagic response. Activated IGF1-PI3K/AKT/mTor cascade may play an important role in a signaling pathway related to the malignant transformation of OLP to OSCC. Recent research has shown that miRNAs, such as miR-199 and miR-122, activate the cascade, increasing the prosurvival and proproliferative signals.
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참고문헌 (70)
참고문헌 신청
Zhang L / 1997 / Molecular analysis of oral lichen planus. A premalignant lesion? / Am J Pathol 151:323~327
Simona Roxana Georgescu / 2017 / Reflectometric Analysis for Identification of Various Pathological Conditions Associated with Lichen Planus / Revista de Chimie 68(5):1103~1108
Giannetti L / 2018 / Oral lichen planus / J Biol Regul Homeost Agents 32:391~395
David Farhi / 2010 / Pathophysiology, etiologic factors, and clinical management of oral lichen planus, part I: facts and controversies / Clinics in Dermatology 28(1):100~108
E. Torrente-Castells / 2009 / Clinical features of oral lichen planus. A retrospective study of 65 cases / Medicina Oral Patología Oral y Cirugia Bucal :e685~e690
Simona Roxana Georgescu / 2017 / Reflectometric Analysis for Identification of Various Pathological Conditions Associated with Lichen Planus / Revista de Chimie 68(5):1103~1108
Giannetti L / 2018 / Oral lichen planus / J Biol Regul Homeost Agents 32:391~395
David Farhi / 2010 / Pathophysiology, etiologic factors, and clinical management of oral lichen planus, part I: facts and controversies / Clinics in Dermatology 28(1):100~108
E. Torrente-Castells / 2009 / Clinical features of oral lichen planus. A retrospective study of 65 cases / Medicina Oral Patología Oral y Cirugia Bucal :e685~e690
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