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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제30권 제6호
- 발행연도
- 2020.1
- 수록면
- 811 - 821 (11page)
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초록· 키워드
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Mycobacterium tuberculosis produces mycolic acids which are relevant for persistence, recalcitrance to antibiotics and defiance to host immunity. c-di-GMP is a second messenger involved in transition from planktonic cells to biofilms, whose levels are controlled by diguanylate cyclases (DGC) and phosphodiesterases (PDE). The transcriptional regulator dosR, is involved in response to low oxygen, a condition likely happening to a subset of cells within biofilms. Here, we found that in M. bovis BCG, expression of both BCG1416c and BCG1419c genes, which code for a DGC and a PDE, respectively, decreased in both stationary phase and during biofilm production. The kasA, kasB, and fas genes, which are involved in mycolic acid biosynthesis, were induced in biofilm cultures, as was dosR, therefore suggesting an inverse correlation in their expression compared with that of genes involved in c-di-GMP metabolism. The relative abundance within trehalose dimycolate (TDM) of α- mycolates decreased during biofilm maturation, with methoxy mycolates increasing over time, and keto species remaining practically stable. Moreover, addition of synthetic c-di-GMP to mid-log phase BCG cultures reduced methoxy mycolates, increased keto species and practically did not affect α-mycolates, showing a differential effect of c-di-GMP on keto- and methoxy-mycolic acid metabolism.
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참고문헌 (53)
참고문헌 신청
Houben RMGJ / 2016 / The global burden of latent tuberculosis infection : a re-estimation using mathematical modelling / PLoS Med 13:e1002152
Menzies NA / 2018 / Progression from latent infection to active disease in dynamic tuberculosis transmission models : a systematic review of the validity of modelling assumptions / Lancet Infect. Dis 18:e228~e238
Voskuil MI / 2003 / Inhibition of respiration by nitric oxide induces a Mycobacterium tuberculosis dormancy program / J. Exp. Med 198:705~713
Mehra S / 2015 / The DosR regulon modulates adaptive immunity and is essential for Mycobacterium tuberculosis persistence / Am. J. Rrespir. Crit. Care Med 191:1185~1196
Flores-Valdez MA / 2016 / Vaccines directed against microorganisms or their products present during biofilm lifestyle: can we make a translation as a broad biological model to Tuberculosis? / Front. Microbiol. 7:14
Menzies NA / 2018 / Progression from latent infection to active disease in dynamic tuberculosis transmission models : a systematic review of the validity of modelling assumptions / Lancet Infect. Dis 18:e228~e238
Voskuil MI / 2003 / Inhibition of respiration by nitric oxide induces a Mycobacterium tuberculosis dormancy program / J. Exp. Med 198:705~713
Mehra S / 2015 / The DosR regulon modulates adaptive immunity and is essential for Mycobacterium tuberculosis persistence / Am. J. Rrespir. Crit. Care Med 191:1185~1196
Flores-Valdez MA / 2016 / Vaccines directed against microorganisms or their products present during biofilm lifestyle: can we make a translation as a broad biological model to Tuberculosis? / Front. Microbiol. 7:14
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