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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제30권 제3호
- 발행연도
- 2020.1
- 수록면
- 333 - 340 (8page)
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Macrophages are the cells of the first-line defense system, which protect the body from foreign invaders such as bacteria. However, Gram-negative bacteria have always been the major challenge for macrophages due to the presence of lipopolysaccharides on their outer cell membrane. In the present study, we evaluated the effect of phloretin, a flavonoid commonly found in apple, on the protection of macrophages from Escherichia coli infection. RAW 264.7 cells infected with standard E. coli, or virulent E. coli K1 strain were treated with phloretin in a dose-dependent manner to examine its efficacy in protection of macrophages. Our results revealed that phloretin treatment reduced the production of nitric oxide (NO) and generation of reactive oxygen species along with reducing the secretion of proinflammatory cytokines induced by the E. coli and E. coli K1 strains in a concentration-dependent manner. Additionally, treatment of phloretin downregulated the expression of E. coli-induced major inflammatory markers i.e. cyclooxygenase-2 (COX-2) and hemeoxygenase-1 (HO-1), in a concentration dependent manner. Moreover, the TLR4-mediated NF-κB pathway was activated in E. coli-infected macrophages but was potentially downregulated by phloretin at the transcriptional and translational levels. Collectively, our data suggest that phloretin treatment protects macrophages from infection of virulent E. coli K1 strain by downregulating the TLR4-mediated signaling pathway and inhibiting NO and cytokine production, eventually protecting macrophages from E. coli-induced inflammation.
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등록된 정보가 없습니다.
참고문헌 (35)
참고문헌 신청
Nathan C / 2002 / Points of control in inflammation / Nature 420:846~852
Gabay C / 2006 / Interleukin-6 and chronic inflammation / Arthritis Res. Ther 8:1~6
Tasneem S / 2019 / Molecular pharmacology of inflammation: Medicinal plants as anti-inflammatory agents / Pharmacol. Res. 139:126~140
Mankhong S / 2019 / 4-Methoxycinnamyl p-coumarate isolated from Etlingera pavieana rhizomes inhibits inflammatory response via suppression of NF-κB, Akt and AP-1 signaling in LPSstimulated RAW 264. 7 macrophages / Phytomedicine 54:89~97
Hirayama D / 2017 / The phagocytic function of macrophage-enforcing innate immunity and tissue homeostasis / Int. J. Mol. Sci. 19:E92
Gabay C / 2006 / Interleukin-6 and chronic inflammation / Arthritis Res. Ther 8:1~6
Tasneem S / 2019 / Molecular pharmacology of inflammation: Medicinal plants as anti-inflammatory agents / Pharmacol. Res. 139:126~140
Mankhong S / 2019 / 4-Methoxycinnamyl p-coumarate isolated from Etlingera pavieana rhizomes inhibits inflammatory response via suppression of NF-κB, Akt and AP-1 signaling in LPSstimulated RAW 264. 7 macrophages / Phytomedicine 54:89~97
Hirayama D / 2017 / The phagocytic function of macrophage-enforcing innate immunity and tissue homeostasis / Int. J. Mol. Sci. 19:E92
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