지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제28권 제6호
- 발행연도
- 2018.1
- 수록면
- 849 - 859 (11page)
이용수
초록· 키워드
오류제보하기
Herpes simplex virus type 2 (HSV-2) infection has been a public health concern worldwide. It is the leading cause of genital herpes and a contributing factor to cervical cancer and human immunodeficiency virus (HIV) infection. No vaccine is available yet for the treatment of HSV- 2 infection, and routinely used synthetic nucleoside analogs have led to the emergence of drug resistance. The small molecule Retro-2cycl has been reported to be active against several pathogens by acting on intracellular vesicle transport, which also participates in the HSV-2 lifecycle. Here, we showed that Retro-2.1, which is an optimized, more potent derivative of Retro-2cycl, could inhibit HSV-2 infection, with 50% inhibitory concentrations of 5.58 μM and 6.35 μM in cytopathic effect inhibition and plaque reduction assays, respectively. The cytotoxicity of Retro-2.1 was relatively low, with a 50% cytotoxicity concentration of 116.5 μM. We also preliminarily identified that Retro-2.1 exerted the antiviral effect against HSV-2 by a dual mechanism of action on virus entry and late stages of infection. Therefore, our study for the first time demonstrated Retro-2.1 as an effective antiviral agent against HSV-2 in vitro with targets distinct from those of nucleoside analogs.
목차
등록된 정보가 없습니다.
참고문헌 (52)
참고문헌 신청
Whitley RJ / 1998 / Herpes simplex viruses / Clin. Infect. Diseases 26:541~553
Gupta R / 2007 / Genital herpes / Lancet 370:2127~2137
Celum CL / 2004 / The interaction between herpes simplex virus and human immunodeficiency virus / Herpes 11(Suppl 1):36A~45A
Wald A / 2002 / Risk of human immunodeficiency virus infection in herpes simplex virus type 2-seropositive persons: a meta-analysis / J. Infect. Dis. 185:45~52
Lehtinen M / 2002 / Herpes simplex virus and risk of cervical cancer: a longitudinal, nested case-control study in the Nordic countries / Am. J. Epidemiol. 156:687~692
Gupta R / 2007 / Genital herpes / Lancet 370:2127~2137
Celum CL / 2004 / The interaction between herpes simplex virus and human immunodeficiency virus / Herpes 11(Suppl 1):36A~45A
Wald A / 2002 / Risk of human immunodeficiency virus infection in herpes simplex virus type 2-seropositive persons: a meta-analysis / J. Infect. Dis. 185:45~52
Lehtinen M / 2002 / Herpes simplex virus and risk of cervical cancer: a longitudinal, nested case-control study in the Nordic countries / Am. J. Epidemiol. 156:687~692
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Inhibition of Herpes Simplex Viruses, Types 1 and 2, by Ginsenoside 20(S)-Rg3
Journal of Microbiology and Biotechnology
2020 .01
-
패션 브랜드의 레트로 마케팅 유형이 레트로 특성 지각과 노스탤지어 감정에 미치는 영향
패션 비즈니스
2022 .02
-
Synthesis and Antiviral Activity Evaluation of 5',5'-Difluoro-2'-methylapiosyl Nucleoside Phosphonic Acid Analogs
조선자연과학논문집
2015 .01
-
노스탤지어 감성이 복고패션 제품의 구매의도에 미치는 영향
복식
2016 .11
-
The Anti-HSV Effect of Quercetin in Raw 264.7 Cells via Downregulation of Inflammatory Responses
한국미생물학회 학술대회논문집
2016 .04
-
Relocation of Paraspeckle Proteins to the Perinucleolar Region during HSV-1 Infection
한국미생물학회 학술대회논문집
2022 .10
-
Correlation between Infection with Multiple Respiratory Viruses and Length of Hospital Stay in Patients from Cheonan, Korea
대한임상검사과학회지
2017 .01
-
사각면 코너 큐브 재귀 반사체의 반사출력광 특성 및 응용
한국광학회지
2015 .02
-
Novel Antiviral Agent against Emerging Influenza Viruses
한국미생물학회 학술대회논문집
2015 .04
-
Diagnostic Methods of Respiratory Virus Infections and Infection Control
대한임상검사과학회지
2021 .01
-
Advancements in Antiviral Drug Development: Comprehensive Insights into Design Strategies and Mechanisms Targeting Key Viral Proteins
Journal of Microbiology and Biotechnology
2024 .07
-
성과 연령에 따른 레트로 패션제품 특성 지각과 소비 감정의 차이 연구
한국생활과학회 학술대회논문집
2022 .05
-
Determination of Antiviral Effects of Adenosine Analogues on Epstein-Barr Virus Infection
한국미생물학회 학술대회논문집
2016 .04
-
Experimental Infection of Hepatitis E Virus in Animal Models
한국미생물학회 학술대회논문집
2019 .04
-
Cellular Stress Responses against Coronavirus Infection: A Means of the Innate Antiviral Defense
Journal of Microbiology and Biotechnology
2024 .01
-
Detection of Antiviral Drugs Resistant Influenza Viruses in Korea during 2016-2017 Season (2017, 10 weeks)
한국미생물학회 학술대회논문집
2017 .04
-
Evaluation of Cell-based Antiviral Activity of Novel Compounds against Zika Virus
한국미생물학회 학술대회논문집
2019 .04
-
A Study on the Aesthetics Characteristics of Retro-Futuristic Fashion
International Journal of Costume and Fashion
2022 .06
-
Structure and Function of the Influenza A Virus Non-Structural Protein 1
Journal of Microbiology and Biotechnology
2019 .01
-
제주특별자치도 종합병원의 감염관리 현황
대한임상검사과학회지
2016 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0