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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 350 - 353 (4page)
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The transcription factor, GATA-1, plays an important role in the FcεRI α chain expression in mast cells and basophils. This study was conducted to investigate the downregulation of the transcription factor GATA-1 by kaempferol isolated from Nelumbo nucifera stamens in FcεRI-mediated allergic reactions. Kaempferol inhibited FcεRI-mediated histamine release. Western blotting analysis and RT-PCR showed that the protein and mRNA expression of GATA-1 was suppressed by kaempferol in a dose-dependent manner. These results suggest that kaempferol may inactivate basophils by downregulating the FcεRI α chain expression via the inhibition of the GATA-1 expression
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참고문헌 (23)
참고문헌 신청
Fujiwara T / 2007 / GATA transcription factors: Basic principles and related human disorders / Tohoku J. Exp. Med 242:83~91
Nei Y / 2013 / GATA-1 regulates the generation and function of basophils / Proc. Natl. Acad. Sci. USA 110:18620~18625
Romeo PH / 1990 / Megakaryocytic and erythrocytic lineages share specific transcription factors / Nature 344:447~449
Martin DI / 1990 / Expression of an erythroid transcription factor in megakaryocytic and mast cell lineages / Nature 344:444~447
Zon LI / 1993 / Expression of mRNA for the GATA-binding proteins in human eosinophils and basophils : potential role in gene transcription / Blood 81:3234~3241
Nei Y / 2013 / GATA-1 regulates the generation and function of basophils / Proc. Natl. Acad. Sci. USA 110:18620~18625
Romeo PH / 1990 / Megakaryocytic and erythrocytic lineages share specific transcription factors / Nature 344:447~449
Martin DI / 1990 / Expression of an erythroid transcription factor in megakaryocytic and mast cell lineages / Nature 344:444~447
Zon LI / 1993 / Expression of mRNA for the GATA-binding proteins in human eosinophils and basophils : potential role in gene transcription / Blood 81:3234~3241
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